Actively Recruiting
Long Term Observation of Ocular Structure and Visual Function in Eyes With High Myopia: Wuhan High Myopia Study
Led by Renmin Hospital of Wuhan University · Updated on 2023-12-27
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying high myopia, a condition defined by a refractive error of -6.00 diopters or worse, or an axial length longer than 26 millimeters. This condition is increasing rapidly worldwide, particularly among younger people, and is expected to cause greater visual impairment in the future. The study aims to observe long-term changes in the eye's fundus structure and visual function in patients with high myopia to provide evidence for better prevention, diagnosis, and prognosis. This is a 4-year prospective observational study involving 1000 participants with high myopia and control subjects, mainly college students. The study uses advanced imaging technologies like optical coherence tomography angiography (OCT-A) and swept-source OCT (SS-OCT) to observe changes in the eye's structure and visual function over time. There are no interventions or treatments given as it is an observational study. Participants will undergo regular assessments at baseline, 6 months, and yearly up to 4 years. These include measurements of optic nerve changes, axial length progression, visual field defects, best corrected visual acuity loss, and myopic maculopathy. Additional evaluations include anterior segment structure, intraocular pressure, mental state, and quality of life. The study is designed to track the progression and effects of high myopia over time to inform future care and prevention strategies.
CONDITIONS
Brief Title
Wuhan High Myopia Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily sign informed consent
- Agree to follow all research procedures and cooperate throughout the study
- Age 18 years or older
- Best corrected visual acuity of 0.1 or better
- For high myopia group: spherical equivalent refraction of -6.00 diopters or worse, or axial length of 26 mm or more
You will not qualify if you...
- Unable or unwilling to sign informed consent
- Unable to cooperate with examinations
- Astigmatism of -1.5 diopters or worse
- Refractive interstitial opacity preventing fundus imaging
- Presence of fundus diseases such as diabetic retinopathy, hypertensive retinopathy, age-related macular degeneration, retinal vein or artery obstruction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo detailed ocular imaging and visual function assessments to establish baseline measurements of eye structure and vision.
1 baseline visit (in-person)
Duration - 4 years
Participants are observed over 4 years with periodic imaging and visual function tests to track changes in eye structure and vision related to high myopia.
Follow-up visits at 6 months and annually for up to 4 years (5 visits total, in-person)
Trial Site Locations
Total: 1 location
1
Renmin Hospital of Wuhan University
Wuhan, Hubei, China, 430060
Actively Recruiting
Research Team
Q
QY Wu, MD
R
RH Hu, bachelor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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