Actively Recruiting
Natural History of Thyroid Function Disorders Understanding Clinical Features and Genetics In Patients with Thyroid Abnormalities
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-05-12
2500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients diagnosed with or suspected to have thyroid function disorders, including hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and TSH-secreting pituitary adenomas. The study aims to better understand the natural history, clinical presentation, and genetics of these conditions. Many tests are performed as part of routine medical care, with additional blood and tissue samples collected for research and genetic analysis. Patients undergo routine history and physical exams, standard endocrine blood and urine tests, a TRH test, thyroid nuclear medicine scans, and thyroid uptake measurements using radioiodine or technetium. Additional imaging such as X-rays, CT scans, or MRIs may be done if clinically needed. The study tracks the causes and progression of thyroid disorders, monitors effects of standard treatments over time, and builds a repository of clinical data and biospecimens for future research. Participants are seen as outpatients or inpatients at the NIH Clinical Center and undergo standard diagnostic procedures and tests throughout the study. Researchers evaluate thyroid disorders continuously, collecting clinical data and biospecimens during care. The study includes individuals aged 6 months to 98 years with known or suspected thyroid abnormalities. There are no exclusion criteria for those meeting inclusion requirements, and the study monitors participants over time to understand disease course and treatment outcomes.
CONDITIONS
Official Title
Natural History of Thyroid Function Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with known or suspected thyroid abnormalities such as hypothyroidism, hyperthyroidism, extreme iodine deficiency, or inherited hypothyroidism due to specific gene abnormalities
- Patients with thyroid function test abnormalities caused by non-thyroidal illness, serum thyroid hormone binding protein abnormalities, genetic deficiency of thyroxine-binding globulin, or antibodies affecting TSH assays
- Willingness to comply with all study procedures and be available for the study duration
- Male or female participants aged 6 months and older
You will not qualify if you...
- There are no exclusion criteria for subjects with known or suspected thyroid abnormalities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
P
Padmasree Veeraraghavan, R.N.
S
Sriram M Gubbi, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here