Actively Recruiting
A2 to O Lung Transplants
Led by University Health Network, Toronto · Updated on 2025-02-06
10
Participants Needed
1
Research Sites
598 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting therapies. Since blood group O lung transplant candidates tend to have longer wait times and a higher waitlist mortality compared to other blood groups, we propose to conduct a prospective study of lung transplantation from blood group A2 donors to eligible blood group O recipients in an effort to increase the available donor pool. The aim of this study is to determine both the feasibility and safety of this specific type of ABO-incompatible lung transplant, and the impact of this practice on reducing transplant wait times among blood group O lung transplant candidates. This would represent the first prospective study of ABO-incompatible lung transplants worldwide.
CONDITIONS
Official Title
A2 to O Lung Transplants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First lung transplant
- Blood group O recipient
- Low pre-operative anti-A antibody titers
- Consent to study participation
You will not qualify if you...
- Re-transplant
- Multiorgan transplant
- Positive virtual crossmatch at time of transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
Research Team
S
Sharaniyaa Balachandran
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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