What is this study trying to find out about airway response after double lung transplantation?

This study aims to understand how the airways react to exercise in people who have had a double lung transplant and how this relates to feelings of breathlessness. Researchers want to compare airway responses during two different exercise durations. The study is sponsored by Chang Gung Memorial Hospital and focuses on better understanding lung function after transplantation.

Who may be eligible for this airway response clinical trial?

Adults aged 20 years and older who have received a double lung transplant at least 3 months ago may be eligible. This trial is open to all genders and excludes those with asthma, significant lung function impairment, or recent infections. Please review eligibility criteria for more details.

Is there any cost to participate in this airway response clinical trial?

Study-related care, including all tests and visits, is provided at no cost. However, personal expenses like travel to the study location may not be covered and can vary. Participants should be prepared for any such costs.

Actively Recruiting

Age: 20Years +

All Genders

ID07035743

Airway Response to Exercise in Adults After Double Lung Transplant Comparing 5-Minute and 15-Minute Exercise Sessions

Led by Chang Gung Memorial Hospital · Updated on 2025-06-25

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to explore how the airways respond to exercise and how this relates to breathlessness in people who have had a double lung transplant. It compares airway responses during two different exercise durations to better understand the effects of physical activity in this group. The study is observational and focuses on lung transplant recipients at least three months after their surgery. Participants will take part in two exercise sessions on separate occasions, each involving constant workload exercise set at 60% of their peak oxygen uptake. One session lasts 5 minutes, and the other lasts 15 minutes, with the order randomized. During exercise, participants will rate their perceived exertion every 5 minutes. Lung function tests measuring forced expiratory volume in 1 second FEV1 will be conducted before exercise, immediately after, and at several intervals up to 30 minutes post-exercise to monitor airway response. Throughout the study, participants will be assessed at multiple time points to track changes in lung function and breathlessness. The main measurement is the percentage change in FEV1 from baseline up to 12 weeks after enrollment. Researchers will closely observe the airway response after exercise to understand the impact of different exercise durations. The total participation timeline includes these repeated assessments to capture short- and longer-term airway changes following exercise.

CONDITIONS

Brief Title

Bronchial Response to Exercise After Double Lung Transplantation

Who Can Participate

Age: 20Years +

All Genders

Eligibility Criteria

You may qualify if you...

Received double lung transplantation
At least 3 months have passed since transplant

You will not qualify if you...

Diagnosis of asthma
Significant airflow limitation (FEV1 predicted 50% or less)
Unable to cooperate with required tests and measurements
Recent infection or transplant rejection within 1 month
Exercise contraindications such as recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, or malignant arrhythmias

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Up to 12 weeks

Participants undergo two exercise sessions of constant workload at 60% of peak oxygen uptake in random order to assess bronchial response. Lung function measurements are taken before, immediately after, and at several intervals following exercise.

2 exercise sessions with lung function testing