Bronchial hyperreactivity after lung transplantation predicts early bronchiolitis obliterans.
M B Stanbrook, S Kesten
https://pubmed.ncbi.nlm.nih.gov/10588625Actively Recruiting
Age: 20Years +
All Genders
ID07035743
Bronchial Response to Exercise After Double Lung Transplantation
Led by Chang Gung Memorial Hospital · Updated on 2025-06-25
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Chang Gung Memorial Hospital
Lead Sponsor
N
National Taiwan University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to explore how the airways respond to exercise and how this relates to breathlessness in people who have had a double lung transplant. It compares airway responses during two different exercise durations to better understand the effects of physical activity in this group. The study is observational and focuses on lung transplant recipients at least three months after their surgery. Participants will take part in two exercise sessions on separate occasions, each involving constant workload exercise set at 60% of their peak oxygen uptake. One session lasts 5 minutes, and the other lasts 15 minutes, with the order randomized. During exercise, participants will rate their perceived exertion every 5 minutes. Lung function tests measuring forced expiratory volume in 1 second (FEV1) will be conducted before exercise, immediately after, and at several intervals up to 30 minutes post-exercise to monitor airway response. Throughout the study, participants will be assessed at multiple time points to track changes in lung function and breathlessness. The main measurement is the percentage change in FEV1 from baseline up to 12 weeks after enrollment. Researchers will closely observe the airway response after exercise to understand the impact of different exercise durations. The total participation timeline includes these repeated assessments to capture short- and longer-term airway changes following exercise.
CONDITIONS
Brief Title
Bronchial Response to Exercise After Double Lung Transplantation
Who Can Participate
Age: 20Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Received double lung transplantation
- At least 3 months have passed since transplant
You will not qualify if you...
- Diagnosis of asthma
- Significant airflow limitation (FEV1 predicted 50% or less)
- Unable to cooperate with required tests and measurements
- Recent infection or transplant rejection within 1 month
- Exercise contraindications such as recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, or malignant arrhythmias
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 12 weeks
Participants undergo two exercise sessions of constant workload at 60% of peak oxygen uptake in random order to assess bronchial response. Lung function measurements are taken before, immediately after, and at several intervals following exercise.
2 exercise sessions with lung function testing
Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital, Linkou Branch
Taoyuan, Taiwan, 33305
Actively Recruiting
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Research Team
M
Mei-Chun Wan
M
Mei-Chun Wan
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation.
David W Reid, E Haydn Walters, David P Johns...
https://pubmed.ncbi.nlm.nih.gov/15797754Lack of bronchial hyperresponsiveness to methacholine and to isocapnic dry air hyperventilation in heart/lung and double-lung transplant recipients with normal lung histology. The Paris-Sud Lung Transplant Group.
P Herve, N Picard, M Le Roy Ladurie...
https://pubmed.ncbi.nlm.nih.gov/1596027Bronchial responsiveness after human heart-lung transplantation.
A R Glanville, J Theodore, J C Baldwin...
https://pubmed.ncbi.nlm.nih.gov/2140767Bronchial responsiveness to exercise after human cardiopulmonary transplantation.
A R Glanville, G M Gabb, J Theodore...
https://pubmed.ncbi.nlm.nih.gov/2666042