Actively Recruiting
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Led by Boston Children's Hospital · Updated on 2025-12-19
60
Participants Needed
1
Research Sites
321 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
CONDITIONS
Official Title
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 8 to 35 years
- Clinical diagnosis of keratoconus and seeking CXL treatment (for CXL group)
- No diagnosis of keratoconus (for control group)
- English speaking ability sufficient to understand consent with parental assistance
- MRI compatible
- Ability to lie still for a 60-minute MRI session
You will not qualify if you...
- Claustrophobia
- Weight over 285 lbs (MRI table limit)
- Current DSM-IV-TR axis I psychiatric disorders
- Chronic pain
- Significant head injury
- Seizures
- Brain tumor
- Cerebrovascular accident
- Neurological disease aside from migraine
- HIV-AIDS
- Use of prescription medication strongly linked to causing dry eyes
- Magnetic implants or metal-containing tattoos on chest or above
- Pregnancy
- History of contact lens wear
- Any allergic reaction to numbing eyedrop in the past
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
E
Eric A Moulton, OD PhD
CONTACT
N
Nicholas J Pondelis, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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