Actively Recruiting
Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site
Led by King Edward Medical University · Updated on 2025-09-25
72
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether Aloe Vera gel dressing reduces pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adults aged 18 to 60 years. This trial aims to see if Aloe Vera leads to improved pain control seven days after surgery and whether it reduces the need for additional pain medication. The study is conducted at the Department of Plastic Surgery over six months and compares two dressing types applied after skin graft surgery. Participants will be randomly assigned to one of two groups: one group receives Aloe Vera gel dressing applied directly to the donor site, followed by dry gauze and crepe bandage as secondary dressings. The other group receives conventional paraffin-based tulle dressing with chlorhexidine applied to the donor site, also followed by dry gauze and crepe bandage. All skin grafts are harvested under general anesthesia using a uniform thickness. The dressings are applied immediately after graft harvesting. During the study, pain will be measured using a visual analogue scale (VAS) on the seventh day after surgery. If participants report a pain score of 4 or higher, they will receive pain medication, and the amount used will be recorded. Researchers will compare the pain scores and analgesic use between the two groups. The total participation time includes surgery and follow-up for at least seven days after surgery to assess pain at the donor site.
CONDITIONS
Brief Title
Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-60 years of either gender needing split-thickness skin graft
You will not qualify if you...
- Patients with altered pain response due to conditions like diabetes, neuropathy, chemotherapy, or opioid use
- Patients allergic to Aloe Vera gel or paraffin-based tulle dressings
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo split-thickness skin grafting under general anesthesia, and the donor site receives either Aloe Vera gel or paraffin-based tulle dressing.
1 visit (in-person)
Duration - 7 days
Participants are monitored for postoperative pain at the donor site and analgesic use is recorded if needed.
1 visit on postoperative day 7 (in-person)
Trial Site Locations
Total: 1 location
1
Mayo Hospital Lahore
Lahore, Punjab Province, Pakistan
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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