Actively Recruiting

Phase Not Applicable
Age: 18Years +
FEMALE
Healthy Volunteers
ID06324942

Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section

Led by University of Calgary · Updated on 2025-03-12

80

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating whether adding a Transversus Abdominis Plane Block (TAP block) improves pain control for patients undergoing a cesarean section. This randomized clinical trial aims to see if this nerve block injection, given into the abdominal wall at the end of surgery, can reduce the need for narcotic pain medications. Previous studies involving other abdominal surgeries suggest that TAP blocks may help patients be more active after surgery and possibly reduce hospital stay time. The study compares two groups: one receiving the surgeon-administered TAP block using 0.25% bupivacaine at a dose of 0.25 mL/kg on each side of the abdomen after uterine closure, and the other receiving no TAP block. The procedure involves precise injection into the transverse abdominis plane under direct visualization during surgery. Patients will not know whether they received the injection, and no sham procedure will be performed. Participants will be monitored for their pain levels 12 hours after surgery as the primary outcome. Secondary outcomes include the time until first request for additional pain relief within 48 hours, total opioid use up to 48 hours post-operation, and the time from surgery until hospital discharge, usually between 1 and 3 days. The trial involves random assignment and double masking to ensure unbiased results, with study-related care provided throughout the hospital stay and follow-up.

CONDITIONS

Brief Title

Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.

Who Can Participate

Age: 18Years +
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • ASA status II to III
  • All patients undergoing elective cesarean section under regional anesthesia at any gestational age
  • Female participants
  • Age 18 years or older
Not Eligible

You will not qualify if you...

  • Known drug allergy to local anesthetics
  • Planned general anesthetic
  • NSAID use contraindicated post partum
  • Chronic pain disorder or chronic narcotic use/dependence
  • Planned vertical abdominal incision
  • Planned Cesarean Hysterectomy
  • Placenta Previa or suspected Placenta Accreta

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Up to 3 days

Participants undergo cesarean section surgery with or without the surgeon-administered Transversus Abdominis Plane (TAP) block for pain management.

1 surgical procedure and hospital stay for up to 3 days

Post-operative Follow-up

Duration - 48 hours post surgery

Participants are monitored for pain levels, opioid use, and time to first request for rescue analgesia after surgery.

Assessments during hospital stay up to 48 hours post surgery

Trial Site Locations

Total: 1 location

1

University of Calgary

Calgary, Alberta, Canada, T2N 2T9

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Research Team

S

Stephen Wood, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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