Study of IgE Proteins in Adults With Allergies and Related Conditions and Healthy Adults

What this Trial Is About

Researchers are investigating the role of IgE proteoforms in various health conditions, including type I allergy, chronic spontaneous urticaria, recent anaphylaxis, mastocytosis, hereditary alpha tryptasemia, X-linked agammaglobulinemia XLA, and in patients undergoing desensitization for venom or medication allergies. The study also includes healthy volunteers to compare findings across these groups. This observational study aims to understand how IgE proteoforms differ among these populations and their potential impact. Participants in this study belong to several groups healthy controls and patients with different allergic or immunological conditions. The study involves collecting blood samples from participants, including those with allergies to medications, venom, food, or airborne allergens, some of whom may be receiving omalizumab treatment. Serial blood sampling is performed to monitor changes over time. During the study, participants will provide blood samples at various time points over four years to evaluate IgE proteoforms. Researchers will collect clinical information regarding allergy severity, medication use, medical history, and laboratory test results. This study involves no treatment interventions and will monitor participants through regular sample collection and clinical assessments to better understand allergy-related immune responses.

Analysis of the Role of IgE Proteoforms in Health and Disease