Study to Diagnose and Identify Allergens in Perioperative Anaphylaxis Using Blood Tests and Skin Testing

What this Trial Is About

Perioperative anaphylaxis is a rare but potentially fatal reaction that can cause serious respiratory and circulatory problems during surgery. Diagnosing and managing this condition is complex due to the combined effects of anesthetic drugs, other medications, and surgical procedures. This study aims to clarify how often severe perioperative anaphylaxis occurs and to identify the allergens involved in surgical patients suspected of having this reaction. The study involves measuring serum tryptase levels, a key biomarker used to distinguish anaphylaxis from other causes. Blood samples to check tryptase will be collected as soon as possible after symptoms appear and again 24 hours later. Additionally, skin testing, including skin prick and intradermal tests, will be performed 4 to 6 weeks after the suspected anaphylaxis to help identify the specific allergens responsible. Participants will be adults or children aged 2 years and older who have suspected perioperative anaphylaxis or a history of such events during surgery. Researchers will monitor tryptase levels on the day of surgery and conduct skin testing weeks later. The main outcomes include the rate of severe perioperative anaphylaxis on the surgery day, the diagnostic rate of anaphylaxis, overall incidence, and allergen identification. Participation lasts through the surgery day and follow-up testing after 4 to 6 weeks.

Diagnosis and Allergen Identification of Perioperative Anaphylaxis