Diagnosis and Allergen Identification of Perioperative Anaphylaxis: a Multicenter Prospective Cohort Study

What this Trial Is About

Perioperative anaphylaxis, a rare but potentially fatal reaction during surgery, is difficult to diagnose and manage due to the complex combination of anesthetic drugs, medications, and surgical effects. This research aims to better understand perioperative anaphylaxis by measuring serum tryptase levels, which help distinguish anaphylaxis from other causes, and by identifying allergens that trigger these reactions using skin tests. The study is a multicenter prospective cohort designed to clarify the incidence and allergen causes of suspected perioperative anaphylaxis cases. The study involves patients aged 2 years and older who have suspected perioperative anaphylaxis during surgery or have a history of such events. Serum samples for tryptase level will be collected promptly after symptom onset and repeated 24 hours later to assist diagnosis. Skin prick and intradermal tests will be performed 4 to 6 weeks after the anaphylaxis event to identify the specific allergens responsible. Participants will be observed on the day of surgery in the operating room, with primary outcomes including the incidence of severe perioperative anaphylaxis. Secondary outcomes include diagnostic rates and allergen detection results. The study is observational, without interventional treatments, and participants’ health and reactions will be closely monitored through blood tests and skin testing over weeks. The study ensures careful evaluation of allergic reactions to improve future management and safety during surgeries.

Diagnosis and Allergen Identification of Perioperative Anaphylaxis