Actively Recruiting
The Effects of Animal- and Microbial-based Protein Sources on Whole-body Protein Metabolism in Healthy Adults
Led by Daniel Moore · Updated on 2025-08-29
13
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
D
Daniel Moore
Lead Sponsor
L
Lesaffre International
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how different animal and microbial-based proteins affect whole-body protein synthesis in healthy adults aged 18 to 45. This study aims to better understand the nutritional quality of these protein sources and their role in maintaining health and body protein mass. The investigation uses a breath test and urine sampling methods developed by the research team to measure protein metabolism. Participants will be randomly assigned to consume one of three test beverages containing yeast protein, whey protein isolate, or collagen protein. Each protein is given as 0.9 grams per kilogram per day, divided into eight hourly drinks. After consuming the test beverage, their whole-body protein metabolism will be monitored over the following 8 hours. During the study, researchers will collect samples and data to measure phenylalanine excretion and oxidation over an 8-hour period as primary outcomes. Participants are expected to comply with study rules and will be monitored for any factors affecting metabolism. The total participation timeline includes the 8-hour metabolic assessment after protein consumption.
CONDITIONS
Brief Title
Animal and Microbial-based Dietary Protein Efficiency in Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy males and females who are recreationally active
- Age between 18 and 45 years
- Willingness to follow the study's compliance rules
- For female participants: self-reported regular menstrual cycle (25-35 days) within the last 3 months
- For female participants: use of monophasic combined oral contraceptives containing 21 active pills (e.g., Yaz, Marvelon, Cyclen)
- Healthy status confirmed by Physical Activity Readiness Questionnaires (PAR-Q+ and others)
You will not qualify if you...
- Inability to follow study compliance rules as judged by the principal investigator, including allergy to dairy protein or yeast
- Regular tobacco use
- Use of illicit drugs such as growth hormone or testosterone
- Participation in studies within the past year involving stable isotopes
- Use of multiphasic combined oral contraceptives
- Use of oral contraceptives containing more than 21 active pills per cycle
- Use of other hormonal contraceptive forms (e.g., progestin-only pill, hormonal IUD, intravaginal ring)
- Current or recent (past 6 months) vegan diet
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Each treatment period lasts 8 hours, repeated for each protein supplement in a crossover design.
Participants consume different protein supplements in separate periods and their whole-body protein metabolism is measured over 8 hours after each consumption.
Multiple visits corresponding to each protein supplement consumption and assessment
Trial Site Locations
Total: 1 location
1
Kinesiology & Physical Education
Toronto, Ontario, Canada, M5S 2C9
Actively Recruiting
Research Team
D
Daniel R. Moore, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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