Actively Recruiting
Led by Texas A&M University · Updated on 2025-10-01
50
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying how changes in metabolism related to aging affect protein turnover in older adults. This research aims to understand how amino acid metabolism contributes to aging-related disorders by measuring whole-body metabolism in a large group of healthy older men and women aged 60 to 80 years. The study uses a specialized pulse method combining multiple stable isotopes to evaluate multiple metabolic pathways simultaneously. Participants will undergo one screening visit lasting about 3 hours and six study days lasting about 8 hours each. On study days, participants will arrive fasting and receive one of six liquid nutritional supplements every 20 minutes for 6 hours. The supplements include different formulations of amino acids and a placebo. Baseline blood samples will be collected before feeding and tracer administration to measure metabolite levels. Throughout the study, researchers will assess body composition, muscle function via tests like the Six-Minute Walk Test, and vital signs. Blood samples will track changes in protein and amino acid metabolism during feeding over up to 6 hours. Participants’ ability to walk, sit, and stand as well as tolerance of lying down for several hours will be evaluated. The study will monitor feeding-related metabolic changes and overall health status during the trial period ending in September 2026.
CONDITIONS
Prandial Metabolic Phenotype in Adults
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 study days
Participants receive one of six liquid nutritional supplements every 20 minutes for 6 hours on each of 6 study days. Each study day involves fasting beforehand and includes baseline blood collection, followed by feeding and tracer administration to assess protein and amino acid metabolism.
6 visits, each approximately 8 hours (in-person)
Total: 1 location
1
Human Clinical Research Facility
College Station, Texas, United States, 77843
Actively Recruiting
M
Marielle Engelen
S
Savanah Knezek
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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Savanah B Knezek, Mariëlle P K J Engelen, Kimberly S Coyle...
https://pubmed.ncbi.nlm.nih.gov/42013668Nicolaas E P Deutz, Savanah B Knezek, Mariëlle P K J Engelen
https://pubmed.ncbi.nlm.nih.gov/41260190