Actively Recruiting
Animal and Plant Proteins and Glucose Metabolism
Led by University of Missouri-Columbia · Updated on 2026-05-08
100
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how different sources of high protein diets affect liver and muscle insulin sensitivity, metabolic response to meals, and 24-hour blood levels of glucose, hormones, and protein-related metabolites linked to metabolic problems. The study focuses on adults aged 21 to 70 with specific body mass index and protein intake criteria, aiming to understand impacts on metabolic syndrome and glucose metabolism disorders. Participants are randomly assigned to one of five groups: a standard protein control group or one of four experimental groups increasing protein intake from animal or plant sources, either as isolates or whole foods. The study monitors changes up to 12 weeks after the dietary intervention, with careful control and comparison among these protein diets. During the study, participants undergo tests including a hyperinsulinemic-euglycemic clamp to measure insulin sensitivity and blood sampling over 24 hours to assess glucose and hormone levels. Other assessments include post-meal glucose and insulin levels, amino acid concentrations, immune cell signaling, and blood vessel function. Researchers track these outcomes to better understand how protein sources influence metabolic health over the trial period.
CONDITIONS
Brief Title
Animal and Plant Proteins and Glucose Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 21 and 70 years
- Body mass index (BMI) between 24.5 and 32.5 kg/m2
- Habitual protein intake less than 0.9 grams per kilogram per day
- Weight stable with less than 3% change and untrained with 150 minutes or less of structured exercise per week for at least 2 months before the study
You will not qualify if you...
- Diagnosis of prediabetes or type 2 diabetes
- Chronic kidney disease with low filtration rate or high urine albumin
- Following vegetarian or vegan diets
- Allergies or intolerance to study meal or diet ingredients
- Use of dietary supplements or medications affecting study outcomes
- Antibiotic or antifungal treatment within 2 months before study
- Use of tobacco products or excessive alcohol consumption
- Significant organ dysfunction or diseases like cirrhosis
- Unable or unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 weeks
Participants follow one of the dietary interventions involving increased protein intake from animal or plant sources.
1 baseline visit and periodic follow-up visits during the intervention
Duration - Up to 12 weeks after the intervention
Participants are monitored for glucose metabolism and related outcomes after completing the dietary intervention.
Periodic visits for outcome assessments
Trial Site Locations
Total: 1 location
1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
B
BETTINA MITTENDORFER
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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