Actively Recruiting
Animal and Plant Proteins and Glucose Metabolism
Led by University of Missouri-Columbia · Updated on 2026-05-08
100
Participants Needed
1
Research Sites
458 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.
CONDITIONS
Official Title
Animal and Plant Proteins and Glucose Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 21 and 70 years
- Body mass index (BMI) greater than 24.5 and less than 32.5 kg/m2
- Habitual protein intake less than 0.9 g/kg/day assessed using a dietary app
- Weight stable with less than 3% change and untrained with 150 minutes or less of structured exercise per week for at least 2 months before the study
You will not qualify if you...
- Diagnosed prediabetes or type 2 diabetes
- Chronic kidney disease shown by medical history or lab tests (glomerular filtration rate less than 60 ml/min/1.73 m2 or urine albumin to creatinine ratio 30 mg/g or higher)
- Vegetarian or vegan diet
- Intolerance or allergies to ingredients in the study meals or diets
- Use of dietary supplements or medications that affect study outcomes
- Antibiotic or antifungal treatment in the 2 months before the study
- Use of tobacco products or excessive alcohol consumption (women more than 14 drinks per week; men more than 21 drinks per week)
- Significant organ diseases such as cirrhosis
- Unable or unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
B
BETTINA MITTENDORFER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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