Actively Recruiting
Aphasia Physical EXercise Study: Randomized Trial
Led by University of California, Berkeley · Updated on 2026-03-19
120
Participants Needed
4
Research Sites
221 weeks
Total Duration
On this page
Sponsors
U
University of California, Berkeley
Lead Sponsor
U
University of California, San Francisco
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is: • Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains? Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting. Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.
CONDITIONS
Official Title
Aphasia Physical EXercise Study: Randomized Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aphasia following ischemic or hemorrhagic stroke
- Aphasia diagnosis confirmed by a standardized language test (Western Aphasia Battery Aphasia Quotient less than 93.8 at study start)
- At least 6 months have passed since the last stroke
- Proficient in English before the stroke
- At least 8 years of education
- Between 18 and 80 years old
- Able to walk independently without a device, except a single-point cane is allowed
- Medically stable with no exercise contraindications as determined by a healthcare provider
You will not qualify if you...
- History of dementia, neurological illness other than stroke, or substance abuse within the last 3 years
- Significant visual or hearing disabilities that interfere with testing, such as neglect or uncorrected impairments
- Uncontrolled cardiorespiratory or metabolic disorders that make exercise unsafe
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University of California, Berkeley
Berkeley, California, United States, 94720
Actively Recruiting
2
California State University, East Bay
Hayward, California, United States, 94542
Actively Recruiting
3
University of San Francisco
San Francisco, California, United States, 94118
Actively Recruiting
4
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
M
Maria Ivanova, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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