Actively Recruiting
Evaluating the Effects of Intensive Speech and Language Rehabilitation Regarding Neuroplasticity, Speech, Language, Communication Skills and Quality of Life for People With Acquired Aphasia and/or Apraxia of Speech in the Chronic Phase
Led by Karolinska Institutet · Updated on 2024-10-31
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
U
University of Malaga
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the short- and long-term effects of an intensive speech-language pathology program combined with physiotherapy on aphasia and apraxia of speech (AOS) in thirty people with chronic stroke. The study aims to assess changes in speech, language, communication, and brain structure and function using standardized speech-language tests and advanced brain imaging methods like voxel-based morphometry and resting state functional connectivity. The goal is to understand how intensive rehabilitation affects neuroplasticity and daily communication abilities in people with these chronic conditions. Participants receive a Multimodal Intensive Rehabilitation program for Aphasia and Apraxia of Speech (MIRAA), an intensive comprehensive aphasia program that includes at least three hours of speech-language training daily over ten days, alongside physical therapy. The therapy is individualized based on participant goals set with a team of speech-language pathologists, physiotherapists, and neurologists. The program features individual therapy, group sessions, and computer-based activities, and includes education for participants and their families about communication and neuroplasticity. During the study, speech-language pathologists conduct evaluations before treatment, immediately after, and again about 16 weeks later, using various speech and communication tests recorded on video and audio for detailed analysis. Brain changes are monitored through imaging techniques focused on language and cognitive processing areas. Researchers measure improvements in language, speech motor planning, communication participation, and quality of life. The total participation duration includes intensive treatment plus follow-up assessments to track lasting effects.
CONDITIONS
Brief Title
Changes in Neuroplasticity Following Intensive Rehabilitation of Aphasia and/or Apraxia of Speech
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Diagnosed with aphasia at least 7 months after stroke by a speech-language pathologist
- Diagnosed with apraxia of speech at least 7 months after stroke by a speech-language pathologist
You will not qualify if you...
- Diagnosis of dementia
- Severe loss of sight
- Severe loss of hearing
- Presence of metal implants preventing MRI scans
- Claustrophobia preventing MRI scans
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 10 days
Participants undergo an intensive speech and language rehabilitation program with additional physiotherapy, focusing on speech, language function, and communicative activity and participation. The program consists of 10 days of training with at least 3 hours of speech-language therapy each day, including individual treatment, group therapy, and computer-based therapy.
10 consecutive daily visits (in-person)
Duration - Approximately 16 weeks after treatment
Participants complete follow-up testing of speech-language, communication, and quality of life approximately 16 weeks after the intensive rehabilitation program to evaluate lasting effects of treatment.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Uppsala Universitet
Uppsala, Sweden, 141 86
Actively Recruiting
Research Team
M
Marika J Schütz, Ph.D student
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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