Evaluating Moderate-Intensity Exercise in Adults with Inactive Inflammatory Bowel Disease to Improve Quality of Life and Clinical Outcomes

What This Trial Is About

Researchers are evaluating the impact of moderate-intensity exercise on quality of life in patients with clinical quiescent Inflammatory Bowel Disease IBD, including Crohns disease and Ulcerative Colitis. This randomized controlled trial aims to explore how exercise relates to symptom recurrence, inflammatory markers, sleep quality, stress levels, and body composition over a six-month period. The study is sponsored by Mahidol University and focuses on prevention in patients whose disease is currently inactive. Participants in the exercise group will be encouraged to engage in moderate-intensity exercise for at least 30 minutes per session, three or more times per week, supervised by a sports scientist. The comparison group will not receive exercise training or supervision. The intervention lasts six months, during which exercise habits and physical activity levels are closely monitored. The study uses a parallel design with quadruple masking to compare outcomes between exercising and non-exercising participants. Throughout the study, participants will undergo assessments at six months including quality of life measures using the Short Inflammatory Bowel Disease Questionnaire SIBDQ, symptom scores, sleep quality, body composition, inflammatory markers in blood and stool, fatigue, and mental health scales. The research team will track adherence and changes in physical activity using questionnaires. The total duration of participation is six months, with safety and disease status monitored regularly to evaluate the relationship between exercise and clinical outcomes in quiescent IBD.

Benefit of Moderate Intensity Exercise in Patients With Clinical Quiescent Inflammatory Bowel Disease