Actively Recruiting
Behavioral Intervention Development Core - Long Term Memory Digital Intervention in Aging
Led by University of California, San Francisco · Updated on 2026-04-02
150
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether two different digital games can help improve long-term memory and cognitive control in older adults, including those with mild cognitive impairment (MCI). The study aims to compare the effects of a navigation game and a word puzzle game on memory performance. This research is conducted as a randomized controlled trial using a web-based platform called Neuroscape Nexus. Participants receive an Apple iPad preloaded with one of two study apps: a navigation game designed to provide an immersive spatial learning experience, or a word puzzle game similar to Boggle. They are asked to complete 45 minutes of training several days a week over 8 weeks, totaling 1000 minutes. The study includes a baseline assessment, an immediate post-training assessment, and a follow-up assessment six months after training ends. All study activities are done remotely from participants' homes. Assessments include surveys and brief tests of memory and attention, each lasting up to 120 minutes and possibly completed over multiple sessions. Researchers will measure changes in recognition memory and cued recall memory immediately after training and at six months follow-up, as well as changes in working memory. Participants receive reminders and track their progress through the study platform throughout their involvement.
CONDITIONS
Brief Title
BID LTM Digital Intervention in Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Minimum of 12 years of education
- Fluent in English
- Normal or corrected-to-normal vision
- Normal or corrected-to-normal hearing
- Medically healthy older adults including those with mild cognitive impairment but without dementia
- Age between 60 and 85 years
You will not qualify if you...
- Under 60 years of age
- Clinical diagnosis of neurological or psychiatric disorder
- Clinical diagnosis of dementia or AD8 score greater than 4
- Vision or hearing impairment not corrected to normal
- Regularly practiced a musical instrument one or more times per week within the last year
- Ten years or more of formal musical instrument training
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for consent and eligibility assessment
Duration - Up to 1 week
Participants complete surveys and brief tests of memory and attention across one or more sessions to establish baseline cognitive function.
Completed remotely in multiple sessions as needed
Duration - Up to 8 weeks
Participants engage with their assigned cognitive training application on a provided tablet at home, completing 45 minutes of training several days a week for up to 8 weeks.
Remote training sessions several days per week totaling 1000 minutes
Duration - Up to 1 week
Participants complete surveys and brief tests of memory and attention across one or more sessions promptly after completing the training regimen.
Completed remotely in multiple sessions as needed
Duration - Single assessment period at 6 months post-training
Six months after post-training tests, participants complete a final series of surveys and brief tests of memory and attention across one or more sessions to assess long-term effects.
Completed remotely in multiple sessions as needed
Trial Site Locations
Total: 1 location
1
University of California, San Francsico
San Francisco, California, United States, 94158
Actively Recruiting
Research Team
M
Melissa Arioli, AB
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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