Actively Recruiting
Randomized Trial of Bilateral Lateral OFC rTMS for Treating Obsessive-Compulsive Disorder in Adults Aged 18 to 65
Led by Centre Hospitalier Henri Laborit · Updated on 2026-01-13
136
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the use of bilateral lateral Orbito Frontal Cortex lOFC repetitive Trans-cranial Magnetic Stimulation rTMS in adults aged 18 to 65 with Obsessive Compulsive Disorder OCD. This study evaluates rTMS as a treatment by targeting both hemispheres of the lOFC, an area shown to be relevant for OCD symptoms. Participants included have not responded to at least two pharmacological treatments for their condition. Participants are randomly assigned to one of two groups one receiving active rTMS stimulation and the other receiving sham placebo stimulation. Both groups undergo two rTMS sessions per day over a period of 10 days. The treatment uses 1 Hz rTMS, a device-based brain stimulation method, applied bilaterally to the lateral OFC. During the study, participants will be assessed using the Yale Brown Obsessive Compulsive Scale at baseline, 25 days, and 70 days to measure OCD symptoms. Additional evaluations include the General Assessment of Functioning GAF and Clinical Global Impression CGI at similar time points. Safety is monitored by recording any adverse events linked to the rTMS treatment. The total study duration includes follow-up assessments up to 70 days after treatment begins.
CONDITIONS
Brief Title
Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder
Research Team
G
Ghina Harika-Germaneau, MD, PhD
N
Nematollah Jaafari, PR
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