Investigating Inflammation and Fibrosis Biomarkers to Predict Conduction Disorders After Transcatheter Aortic Valve Implantation in Severe Aortic Stenosis Patients

What this Trial Is About

This research aims to better understand the prediction of conduction disorders CDs in patients with severe aortic stenosis AS who undergo transcatheter aortic valve implantation TAVI. Since new-onset CDs and the need for permanent pacemaker implantation PPI after TAVI can affect patient outcomes, this observational prospective trial studies the role of inflammation and fibrosis biomarkers in predicting these complications. Identifying patients at higher risk could help tailor treatment and monitoring strategies. Before the TAVI procedure, blood samples will be taken from participants to analyze various biomarkers related to inflammation and fibrosis, including C-reactive protein, procalcitonin, interleukin-6, calprotectin, lactate-dehydrogenase, ferritin, and others. A subgroup of 40 patients will have additional analysis of specific microRNAs linked to fibrosis and inflammation. Echocardiographic measures will assess cardiac damage and fibrosis. Patients will be monitored with electrocardiograms before, during hospitalization, and at a three-month follow-up to detect new-onset CDs or PPI. Participants will be grouped based on whether they develop new conduction disorders or receive a pacemaker during hospitalization and follow-up. The study will measure biomarker levels before TAVI and compare them with clinical outcomes. Ongoing ECG monitoring and echocardiographic assessments will help track heart function and conduction status. The trial is expected to continue until August 2026, involving detailed laboratory and imaging evaluations to understand the link between biomarkers and conduction complications after TAVI.

Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI