Actively Recruiting
Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI
Led by Clinical Hospital Center Rijeka · Updated on 2025-10-06
102
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
Sponsors
C
Clinical Hospital Center Rijeka
Lead Sponsor
U
University of Rijeka, Medical Faculty
Collaborating Sponsor
AI-Summary
What this Trial Is About
Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes. The goal of this observational prospective trial is to investigate the role of pre-procedural values of systemic biomarkers of inflammation and fibrosis in the prediction of new-onset CDs and permanent pacemaker implantation (PPI) in patients undergoing the TAVI procedure.
CONDITIONS
Official Title
Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written consent to participate in the trial
- Diagnosis of severe AS according to current European Society of Cardiology (ESC) guidelines for valvular heart disease
You will not qualify if you...
- Acute infectious disease
- Chronic inflammatory or autoimmune disease
- Corticosteroid or other immunosuppressive therapy
- Active malignant disease
- Liver disease accompanied by dysfunction
- Permanent pacemaker implanted previously
- An acute myocardial infarction within three months before the procedure
- A surgical procedure within three months before the procedure
- Previous surgical or transcatheter aortic valve replacement/implantation
- End-stage chronic kidney disease (eGFR <15 ml/min)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Clinical Hospital Center Rijeka
Rijeka, Croatia, Croatia, 51000
Actively Recruiting
Research Team
G
Gordana Bačić, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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