Study of Blood Flow and Sound in Arteriovenous Fistulas for Patients with End-Stage Renal Disease Using MRI and Ultrasound to Improve Hemodialysis Access Monitoring

What this Trial Is About

Researchers are studying the connection between blood flow conditions and the sounds produced by arteriovenous fistulas AVFs in patients with end-stage renal disease ESRD who require vascular access for hemodialysis. This study aims to better understand how blood flow affects AVF function and to explore if analyzing these sounds can help predict AVF health. The trial focuses on non-drug methods to improve AVF monitoring and reduce failures. Participants will have an AVF surgically created and then undergo several diagnostic tests including non-contrast enhanced MRI scans and advanced 3D ultrasound examinations to create detailed blood flow models. The study includes a series of visits starting with screening and enrollment, surgery day, and follow-up visits at 0-14 days, 3 months, 6 months, 1 year, and 2 years post-surgery to monitor AVF condition and sounds. During the study, participants will be assessed through imaging and sound analysis to measure blood flow patterns and their relationship with AVF vibrations and sounds. Researchers will track the correlation between blood flow disturbances and sound features at each visit. The study will measure how well sound analysis can indicate AVF health over two years, helping develop new, non-invasive monitoring tools. Safety and health status will be regularly checked throughout the follow-up period.

Blood Flow Conditions and Sounds in AVFs