Brain Blood Vessel Responses to Changes in Blood Flow in Adults Aged 20 to 40

What this Trial Is About

The trial investigates how brain blood flow changes in younger adults aged 20 to 40 years during specific challenges. It aims to explore cerebrovascular control during acute physiological events like simulated postural changes and increased carbon dioxide breathing, addressing gaps in knowledge about blood flow regulation that may relate to cognitive impairment. This research is sponsored by the University of Wisconsin, Madison and focuses on basic science in brain circulation. Participants will undergo magnetic resonance imaging MRI scans while performing tasks that simulate postural changes and while breathing higher levels of carbon dioxide. They will receive either a dose of prazosin based on body weight or an oral placebo as part of the study interventions. The study includes two visits, each lasting up to 240 minutes, to measure changes in blood velocity and blood flow. During the study, participants will be monitored through MRI scans while completing the physiological tasks. Researchers will assess changes in cerebral blood velocity and flow to evaluate cerebrovascular responses. The trial involves healthy volunteers and includes detailed eligibility screening. Participants can expect two study visits, with close monitoring of brain blood flow and safety throughout the process. The study is planned to be completed by May 2027.

Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort