Actively Recruiting

Phase 2
Age: 20Years - 40Years
All Genders
Healthy Volunteers
NCT06629090

Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

Led by University of Wisconsin, Madison · Updated on 2025-12-18

36

Participants Needed

1

Research Sites

49 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

CONDITIONS

Official Title

Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

Who Can Participate

Age: 20Years - 40Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Between the ages of 20-40 years
  • Have a BMI 4.5 kg/m2
  • Are less than 72 in (182.88 cm) height
  • Nonsmoker
Not Eligible

You will not qualify if you...

  • Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
  • History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
  • History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
  • Uncontrolled hypertension
  • History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
  • Severe untreated obstructive sleep apnea
  • History of diabetes with HbA1c greater than 9.5 percent
  • Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
  • Current or recent (less than1 year) major psychiatric condition (Axis I) or addictive disorders
  • Significant surgical history
  • Other significant medical conditions at investigators' discretion
  • Contraindications to MRI
  • Prescribed medications that interfere with prazosin
  • Lactose allergy
  • Lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Wisconsin

Madison, Wisconsin, United States, 53705

Actively Recruiting

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Research Team

A

Anna Howery

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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