Characterization of Acute Myocardial Damage With Spectral Computed Tomography. CADAMI-SPECTRAL.

What this Trial Is About

Researchers are investigating the use of spectral computed tomography (CT) to better diagnose acute myocardial injury conditions such as myocarditis, stress cardiomyopathy, and myocardial infarction with normal coronary arteries (MINOCA). This observational study compares spectral CT findings with cardiac magnetic resonance imaging (cMRI), the current gold standard, to assess if spectral CT can provide similar or additional diagnostic information. The study also plans to use artificial intelligence to analyze imaging results and will follow participants for one year to evaluate prognostic value. The study involves 150 patients suspected of having acute myocardial injury who will undergo spectral CT scans alongside standard cMRI scans. A control group of 150 patients without coronary or structural heart disease will also receive cardiac CT for comparison. The spectral CT uses iodine-based contrast to create detailed images of heart tissue perfusion and delayed iodine enhancement, aiming to characterize different patterns of myocardial damage in a single imaging procedure. Participants will be monitored with imaging tests, including spectral CT and cMRI, and followed for up to two years to correlate imaging findings with heart tissue abnormalities. Researchers will analyze volumes of myocardium with abnormal perfusion and late gadolinium enhancement to understand tissue damage. The study includes clinical assessments, imaging comparisons, and a one-year follow-up to evaluate the predictive value of spectral CT findings for patient outcomes.

Characterization of Acute Myocardial Damage With Spectral Computed Tomography. (CADAMI-SPECTRAL)