Coronally advanced flaps (CAF) plus connective tissue graft (CTG) is the gold standard for treatment of Miller class I and II gingival defects.
Martha E Nunn, Takanari Miyamoto
https://pubmed.ncbi.nlm.nih.gov/24237738/Actively Recruiting
Led by Tufts University · Updated on 2026-04-29
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
This research aims to evaluate treatments for gum recession, a condition where the roots of teeth become exposed. It compares two commonly used soft tissue grafting methods to see how well they work over time. The study is sponsored by Tufts University and involves adults interested in corrective surgery for aesthetic reasons or tooth sensitivity. Participants will receive two types of tissue graft procedures connective tissue graft CTG on one side of the mouth and platelet-rich fibrin PRF on the other side. Both methods are standard care for gum recession and are applied in a split-mouth design, meaning each participant receives both treatments for comparison. The study uses an intraoral scanner before and after treatment to measure changes in tissue volume. Participants will have a total of 12 visits over five years to monitor healing and assess the success of each grafting method. At each visit, scans will be taken to evaluate the volume of gum tissue. Researchers will compare the two procedures based on these measurements over the long term. The study also includes follow-up to ensure participants adhere to the treatment and monitoring plan.
CONDITIONS
Changes of Soft Tissue Grafting: A Randomized Study
T
Tannaz Shapurian, DDM, MSc
A
Ann-Marie Jacobson
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Tufts University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Platelet-rich fibrin (PRF) | Autogenous connective tissue graft (CTG) |
|---|---|---|
| What it is | A root coverage procedure using platelet-rich fibrin (PRF) as the adjunct to flap surgery at sites with gingival recession. | A root coverage procedure using a patient's own connective tissue graft (CTG), harvested from the palate, as the adjunct to flap surgery at sites with gingival recession. |
| Role in the trial | Serves as the test treatment to evaluate whether PRF is at least as effective as CTG for root coverage in gingival recession. | Serves as the within-participant control and standard treatment for comparison with PRF in the same mouth. |
| Primary clinical use | PRF is investigated as an option to promote soft tissue healing and achieve root coverage in areas with gingival recession. | CTG is used to restore gum tissue and provide predictable root coverage, especially in multiple sites and Miller class I and II recession defects. |
| How it is given or performed | After preparing the site, PRF is placed under a flap over the exposed root, followed by flap repositioning and closure. | A piece of the participant's connective tissue is harvested (usually from the palate), positioned under a flap at the recession site, and the flap is advanced and sutured in place. |
| Evidence status | PRF is being evaluated as a less invasive option for root coverage; clinical evidence is growing but its predictability compared with CTG is still under investigation. | CTG is widely regarded as the gold standard for root coverage in Miller class I and II recession defects; its effectiveness is well supported in clinical literature. |
| Important limitations | Long-term effectiveness and predictability of PRF for root coverage are not as well established as CTG, and there may be variation in clinical protocols and PRF preparation methods. | CTG procedures often involve a second surgical site to harvest tissue, which can increase patient discomfort, and may be more technically demanding for the clinician. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure with follow-up visits over 5 years
Participants receive soft tissue grafting with two procedures: autologous platelet-rich fibrin (PRF) on one side of the mouth and autogenous connective tissue graft (CTG) on the other side.
12 visits over 5 years
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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https://pubmed.ncbi.nlm.nih.gov/29087001/Tufts University
Lead Sponsor