Coronally advanced flaps (CAF) plus connective tissue graft (CTG) is the gold standard for treatment of Miller class I and II gingival defects.
Martha E Nunn, Takanari Miyamoto
https://pubmed.ncbi.nlm.nih.gov/24237738Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05633511
Volumetric Changes of Soft Tissue Grafting Comparing Autologous Platelet-rich Fibrin and Autogenous Connective Tissue Grafts in a Split-mouth Randomized Design
Led by Tufts University · Updated on 2026-04-29
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate treatments for gum recession, a condition where the roots of teeth become exposed. It compares two commonly used soft tissue grafting methods to see how well they work over time. The study is sponsored by Tufts University and involves adults interested in corrective surgery for aesthetic reasons or tooth sensitivity. Participants will receive two types of tissue graft procedures: connective tissue graft (CTG) on one side of the mouth and platelet-rich fibrin (PRF) on the other side. Both methods are standard care for gum recession and are applied in a split-mouth design, meaning each participant receives both treatments for comparison. The study uses an intraoral scanner before and after treatment to measure changes in tissue volume. Participants will have a total of 12 visits over five years to monitor healing and assess the success of each grafting method. At each visit, scans will be taken to evaluate the volume of gum tissue. Researchers will compare the two procedures based on these measurements over the long term. The study also includes follow-up to ensure participants adhere to the treatment and monitoring plan.
CONDITIONS
Brief Title
Changes of Soft Tissue Grafting: A Randomized Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Need treatment for gum recession at two or more sites (RT I and II, Cairo classification)
- Class A +/-
- No class V restoration present
You will not qualify if you...
- Patients who do not consent to recommended therapy
- Patients who smoke
- Patients unable to comply with follow-up visits
- Patients who self-report as pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single procedure with follow-up visits over 5 years
Participants receive soft tissue grafting with two procedures: autologous platelet-rich fibrin (PRF) on one side of the mouth and autogenous connective tissue graft (CTG) on the other side.
12 visits over 5 years
Trial Site Locations
Total: 1 location
1
Tufts University School of Dental Medicine
Boston, Massachusetts, United States, 02111
Actively Recruiting
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Research Team
T
Tannaz Shapurian, DDM, MSc
A
Ann-Marie Jacobson
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Published Research Related To This Trial
A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller's class-I and II recession defects.
Rajan Padma, Ande Shilpa, Pavaluri Aravind Kumar...
https://pubmed.ncbi.nlm.nih.gov/24174758Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects?
Leandro Chambrone, Daniela Chambrone, Francisco E Pustiglioni...
https://pubmed.ncbi.nlm.nih.gov/18584934Soft-Tissue Changes After Using Collagen Matrix Seal or Collagen Sponge With Allograft in Ridge Preservation: A Randomized Controlled Volumetric Study.
Zuhair S Natto, Andreas O Parashis, Y Natalie Jeong
https://pubmed.ncbi.nlm.nih.gov/32369569Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: Randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life.
Maurizio S Tonetti, Pierpaolo Cortellini, Gaia Pellegrini...
https://pubmed.ncbi.nlm.nih.gov/29087001Treatment of multiple areas of gingival recession using a simple harvesting technique for autogenous connective tissue graft.
Dwight E McLeod, Elio Reyes, Grishondra Branch-Mays
https://pubmed.ncbi.nlm.nih.gov/19792859Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial.
Huseyin Gencay Keceli, Dilek Sengun, Atilla Berberoğlu...
https://pubmed.ncbi.nlm.nih.gov/18190557