China Research Registry on Emergency Surgery and Conservative Treatment for Severe Spontaneous Intracerebral Hemorrhage in Adults Receiving Long-Term Antiplatelet Therapy

What this Trial Is About

Researchers are studying patients with severe spontaneous intracerebral hemorrhage SSICH, a type of brain bleeding, focusing on those who are on long-term oral antiplatelet therapy LOAPT. The study aims to evaluate how emergency surgery compares to standard conservative treatment in terms of survival and safety. This registry study, called CRISIH, is ongoing and gathers data from multiple centers in China over a planned 10-year period starting in 2019, with a special interest in surgical outcomes and complications for these patients. Participants receive either emergency neurosurgery to evacuate the brain hemorrhage or conservative treatments as determined by routine clinical practice. The registry collects detailed clinical, radiological, surgical, and laboratory information about each patient. Follow-up includes assessments up to six months post-hemorrhage for mortality, as well as monitoring for surgical complications and disorders of consciousness at multiple time points post-surgery. During the study, participants health data are regularly recorded, including postoperative bleeding events and consciousness status measured by the Coma Recovery Scale-Revised at 30, 90, 180, and 365 days after surgery. The main outcome measured is total mortality from hospital admission through six months after the initial hemorrhage. The study continues to enroll and follow patients beyond the initial five years, with ongoing data collection to enhance understanding of treatment effects and safety.

China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）