Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in Patients With Disorders of Consciousness

What this Trial Is About

Disorders of Consciousness (DoC) occur as a result of severe brain injuries from causes like traumatic brain injury, stroke, cardiac arrest, and other neurological or systemic diseases. The increasing number of survivors with DoC presents significant challenges for healthcare and families. Accurate diagnosis and classification of DoC patients are essential for guiding treatment and improving quality of life. Behavioral assessments like the Coma Recovery Scale-Revised (CRS-R) are commonly used but can be limited in distinguishing subtle differences, especially between Vegetative State/Unresponsive Wakefulness Syndrome and Minimally Conscious State patients. This research evaluates the use of interoception-related indicators, specifically using rectal stimulation combined with electroencephalogram (EEG) recordings, to better classify DoC patients. Interoception involves brain communication with internal organs and may remain relatively intact in DoC patients. The study uses a device that inflates a rectal balloon rapidly to stimulate internal signals, recording brain responses via EEG across multiple stimulations. This method aims to add valuable information beyond traditional behavioral assessments. Participants will undergo rectal balloon stimulation while EEG monitors brain activity, with 35 stimulations delivered during the session. Researchers will assess the diagnostic value of these interoceptive EEG indicators to help differentiate levels of consciousness. The study spans from December 2024 to December 2025, with ongoing monitoring and data collection. This approach could provide a more cost-effective and convenient complement to imaging techniques and behavioral tests in evaluating DoC patients.

Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in DoC