Study of Cognitive Changes in Children Ages 7 to 10
Observing Behavior and Brain Imaging Over Time
Led by Radboud University Medical Center · Updated on 2025-04-11
600
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating cognitive variability in children aged 7 to 10 at their first assessment. This observational study aims to understand how cognitive differences vary between individuals, explore the brain, psychological, and environmental factors influencing these differences, and examine the long-term effects and outcomes related to cognitive variability. The study uses advanced methods including experience sampling, longitudinal designs, and deep phenotyping to answer these questions.
Participants may take part in either a behavioural or a behavioural with imaging arm. The behavioural arm includes children aged 7 to 10, while the imaging arm is for children aged 8 to 10 at the first assessment. The imaging arm involves MRI scans such as MP-RAGE, diffusion weighted imaging, and functional MRI during cognitive tasks. Assessments are done at baseline and followed up two years later for imaging, with cognitive task reaction times and questionnaire scores tracked through an average of three years.
During the study, children will complete various cognitive tasks measuring reaction times in vocabulary, working memory, speed, fluid reasoning, and exploration. Mood and sleep scores are also tracked using smiley sliders. Imaging participants will undergo baseline and follow-up MRI scans with naturalistic viewing and reasoning tasks. Parents will provide questionnaire data and reaction times on cognitive tasks. Researchers will assess cognitive performance, brain activity, psychological traits, and environmental factors to understand cognitive variability and its outcomes over time.
CONDITIONS
Brief Title
COgnitive Dynamics in Early Childhood
Research Team
R
Rogier Kievit
I
Ilse Coolen
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match. Sign up to get personalized trial recommendations delivered to your inbox.
Children between 7 and 10 years old for the behavioural part of the study
Children between 8 and 10 years old for the imaging part of the study
You will not qualify if you...
Not understanding instructions for behavioural tasks due to a language barrier
History of neurological or psychiatric illness (imaging arm)
History of using psychotropic medications (imaging arm)
Contraindications for MRI (imaging arm)
Presence of metal parts on or in the upper body that cannot be removed (except dental fillings, crowns, metal wire behind teeth, tattoos, contraceptive coils) (imaging arm)
Metal fragments in the body, especially in the eye (imaging arm)
History of brain surgery (imaging arm)
Having active implants such as pacemaker, neurostimulator, insulin pump, or ossicle prosthesis (imaging arm)
Using medical plasters that cannot or should not be removed (e.g., nicotine plaster) (imaging arm)
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Approximately 1 year
Participants undergo baseline cognitive and imaging assessments including MRI scans and behavioral tests.
1 baseline visit (in-person)
Long-term Monitoring
Duration - Up to 3 years
Participants are observed over time with repeated cognitive assessments and questionnaires to track changes.
Repeated assessments throughout the study period
Diagnostic Evaluation
Duration - 1 day
Participants complete follow-up cognitive and imaging assessments two years after baseline.
1 follow-up visit (in-person) at two years after baseline
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Study Comparing Personalized and Fixed Amplitude ECT for Depression in Adults Over 50
Motivational Interviewing and Electronic Messaging to Improve Sleep Apnea Treatment and Cognitive Health in American Indian Elders
Study of Cognitive Changes in Children Ages 7 to 10
Observing Behavior and Brain Imaging Over Time
Study on Cognitive Effects of Neoadjuvant Chemotherapy in Women with Advanced Ovarian Cancer
Study of Brain Changes and Thinking Problems in Adults with Colorectal Cancer Receiving Chemotherapy
Early Cognitive Changes in People 70 Years and Older After Same-Day Discharge Hip and Knee Replacement Surgery
Evaluating Two Digital Cognitive Training Programs for Cancer Survivors with Cognitive Complaints After Chemotherapy Treatment
Study of Cognitive Training Effects in Younger 18-30 and Older Adults 60-85
Study of Different Executive Function Training Methods in Adolescents Aged 12 to 17 With and Without ADHD
Effects of Cardio-Dance Fitness Versus Strength, Flexibility, and Balance Exercises on Brain Health and Alzheimers Risk in Older African Americans
Have more questions? Get in touch with our team for quick support
Published Research Related To This Trial
Protocol and preregistration for the CODEC project: measuring, modelling and mechanistically understanding the nature of cognitive variability in early childhood.
Ilse E J I Coolen, Jordy van Langen, Sophie Hofman...