Actively Recruiting
Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2023-02-06
1000
Participants Needed
1
Research Sites
1121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.
CONDITIONS
Official Title
Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 40 years or older
- No known dementia or stroke (including cerebral infarction and hemorrhage)
You will not qualify if you...
- Any contraindications to MRI
- Serious head injury causing loss of consciousness or previous brain surgery
- Current cancer diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The second affiliated hospital of Zhejiang University
Hangzhou, China, 310000
Actively Recruiting
Research Team
M
Min Lou, Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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