Adverse cerebral effects of anaesthesia on old people.
P D BEDFORD
https://pubmed.ncbi.nlm.nih.gov/13243706Actively Recruiting
Phase Not Applicable
Age: 60Years +
All Genders
ID06339268
Effects of Preoperative Cognitive and Physical Optimization in the Prevention of Postoperative Cognitive Deficit in Elderly Patients With Lung Resection
Led by Military Medical Academy, Belgrade, Serbia · Updated on 2025-04-24
120
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on elderly patients undergoing lung resection surgery and aims to evaluate ways to prevent postoperative cognitive problems such as delirium and cognitive dysfunction. These issues can arise after surgery and general anesthesia, especially in older adults who are frail or have complications. The study explores how preoperative cognitive and physical preparation may affect recovery and cognitive outcomes after major surgery. Participants will be randomly assigned to one of two groups. The intervention group will receive cognitive training using a mobile application called Cognifit three times a week for 20 minutes over one month before surgery. They will also undergo physical therapy including breathing exercises, walking, and stair climbing, plus education on postoperative exercises to do in bed. The control group will receive standard care without the cognitive or physical prehabilitation. During the study, participants will be assessed before surgery and up to 30 days after surgery for cognitive function, delirium, anxiety, depression, and physical recovery. Researchers will use psychological tests, weakness syndrome assessments, and functional status evaluations. Patients will keep diaries of their preoperative activities. The study will also monitor complications, morbidity, and mortality up to 30 days post-surgery to understand overall outcomes and recovery patterns.
CONDITIONS
Brief Title
Cognitive and Physical Optimization in Prevention of Postoperative Cognitive Deficit in Elderly With Lung Resection
Who Can Participate
Age: 60Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Older than 60 years
- Elective lung resection operations
- Patients who can use a phone or tablet
- Patients who agreed to participate in the study
- Clinical scale of weakness less than 6
- The American Society of Anesthesiologists (ASA) status I, II, III, IV
You will not qualify if you...
- Under 60 years of age
- Significant psychiatric comorbidity (schizophrenia, depression, alcoholism)
- Significant neurological comorbidity (dementia, cerebrovascular insult in the last 6 months, parkinsonism)
- Patient's refusal to participate in the study
- The inability of the patient to use a tablet or phone
- The American Society of Anesthesiologists (ASA) status V and VI
- Clinical weakness scale 6 and above
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Run-in Period
Duration - 1 month
Participants in the intervention group receive preoperative cognitive stimulation using a cognitive training app and physical therapy exercises to prepare for surgery. Participants in the control group receive standard care without these preoperative interventions.
Approximately 12 sessions of cognitive training (3 times per week) plus physical therapy activities
Surgery
Duration - Day of surgery
Participants undergo lung resection surgery.
1 visit (in-person surgery)
Post-operative Follow-up
Duration - 30 days
Participants are monitored for cognitive function, delirium, depression, anxiety, functional status, and recovery during the first 30 days following surgery.
Visits and assessments during 1 to 5 days post-surgery and follow-up visits until day 30
Trial Site Locations
Total: 1 location
1
Military Medical Academy
Belgrade, Serbia, 11000
Actively Recruiting
Loading map...
Research Team
V
Vojislava Neskovic, PhD
M
Marija Markovic, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Should general anaesthesia be avoided in the elderly?
C Strøm, L S Rasmussen, F E Sieber
https://pubmed.ncbi.nlm.nih.gov/24303859Postoperative cognitive dysfunction and dementia: what we need to know and do.
M J Needham, C E Webb, D C Bryden
https://pubmed.ncbi.nlm.nih.gov/29161395Prehabilitation for the Anesthesiologist.
Francesco Carli
https://pubmed.ncbi.nlm.nih.gov/32358253Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence.
Lori A Daiello, Annie M Racine, Ray Yun Gou...
https://pubmed.ncbi.nlm.nih.gov/31166241Postoperative cognitive dysfunction: current developments in mechanism and prevention.
Wei Wang, Yan Wang, Haibo Wu...
https://pubmed.ncbi.nlm.nih.gov/25306127An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions.
Taiki Sugimoto, Hidenori Arai, Takashi Sakurai
https://pubmed.ncbi.nlm.nih.gov/34882939The Association of Preoperative Frailty and Postoperative Delirium: A Meta-analysis.
Thomas J Gracie, Christine Caufield-Noll, Nae-Yuh Wang...
https://pubmed.ncbi.nlm.nih.gov/34257192Prehabilitation.
James Durrand, Sally J Singh, Gerry Danjoux
https://pubmed.ncbi.nlm.nih.gov/31732585Effect of preoperative cognitive and physical optimization in the prevention of postoperative cognitive deficit in elderly patients with lung resection - cognition trial.
Vojislava Neskovic, Marija Markovic, Nebojsa Maric...
https://pubmed.ncbi.nlm.nih.gov/41387902