What is this study trying to find out about postoperative cognitive problems after lung surgery?

This study is evaluating whether preoperative cognitive training and physical therapy can help prevent cognitive problems like delirium and dysfunction after lung resection in older adults. The research aims to improve recovery and reduce complications in elderly patients undergoing major surgery.

Who may be eligible for this prehabilitation clinical trial?

Adults aged 60 years or older who are scheduled for elective lung resection and can use a phone or tablet may be eligible. Both men and women can participate. Important factors include having a clinical weakness score less than 6 and no major psychiatric or neurological conditions. Please review eligibility criteria for more details.

Is there any cost to participate in this prehabilitation clinical trial?

Study-related care, including the cognitive training, physical therapy, and all trial visits, is provided at no cost. Personal travel and other expenses may vary and are usually not covered. Participants can expect the study treatments and visits without direct charges.

Actively Recruiting

Phase Not Applicable

Age: 60Years +

All Genders

ID06339268

Preoperative Cognitive and Physical Training to Prevent Cognitive Problems After Lung Surgery in Older Adults

Led by Military Medical Academy, Belgrade, Serbia · Updated on 2025-04-24

120

Participants Needed

Research Sites

17 weeks

Total Duration

AI-Summary

What this Trial Is About

This research focuses on elderly patients undergoing lung resection surgery and aims to evaluate ways to prevent postoperative cognitive problems such as delirium and cognitive dysfunction. These issues can arise after surgery and general anesthesia, especially in older adults who are frail or have complications. The study explores how preoperative cognitive and physical preparation may affect recovery and cognitive outcomes after major surgery. Participants will be randomly assigned to one of two groups. The intervention group will receive cognitive training using a mobile application called Cognifit three times a week for 20 minutes over one month before surgery. They will also undergo physical therapy including breathing exercises, walking, and stair climbing, plus education on postoperative exercises to do in bed. The control group will receive standard care without the cognitive or physical prehabilitation. During the study, participants will be assessed before surgery and up to 30 days after surgery for cognitive function, delirium, anxiety, depression, and physical recovery. Researchers will use psychological tests, weakness syndrome assessments, and functional status evaluations. Patients will keep diaries of their preoperative activities. The study will also monitor complications, morbidity, and mortality up to 30 days post-surgery to understand overall outcomes and recovery patterns.

CONDITIONS

Brief Title

Cognitive and Physical Optimization in Prevention of Postoperative Cognitive Deficit in Elderly With Lung Resection

Who Can Participate

Age: 60Years +

All Genders

Eligibility Criteria

You may qualify if you...

Older than 60 years
Elective lung resection operations
Patients who can use a phone or tablet
Patients who agreed to participate in the study
Clinical scale of weakness less than 6
The American Society of Anesthesiologists (ASA) status I, II, III, IV

You will not qualify if you...

Under 60 years of age
Significant psychiatric comorbidity (schizophrenia, depression, alcoholism)
Significant neurological comorbidity (dementia, cerebrovascular insult in the last 6 months, parkinsonism)
Patient's refusal to participate in the study
The inability of the patient to use a tablet or phone
The American Society of Anesthesiologists (ASA) status V and VI
Clinical weakness scale 6 and above

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Run-in Period

Duration - 1 month

Participants in the intervention group receive preoperative cognitive stimulation using a cognitive training app and physical therapy exercises to prepare for surgery. Participants in the control group receive standard care without these preoperative interventions.

Approximately 12 sessions of cognitive training (3 times per week) plus physical therapy activities

Surgery

Duration - Day of surgery

Participants undergo lung resection surgery.

1 visit (in-person surgery)

Post-operative Follow-up

Duration - 30 days

Participants are monitored for cognitive function, delirium, depression, anxiety, functional status, and recovery during the first 30 days following surgery.

Visits and assessments during 1 to 5 days post-surgery and follow-up visits until day 30