Study of Women Aged 18 to 50 with Unexplained Recurrent Early Miscarriages or Implantation Failures to Understand Causes and Improve Care

What this Trial Is About

Researchers are investigating women who experience unexplained repeated early miscarriages or recurrent implantation failures. This study focuses on women aged 18 to 50 who have had at least three early pregnancy losses before 14 weeks or three failed embryo transfers. The research aims to better understand the causes of these pregnancy challenges, including possible immune system problems and genetic factors, by following patients over several years. Participants are observed as part of their routine medical care in internal medicine or obstetrics-gynecology. On the day they join the study, their medical and pregnancy histories are reviewed, including lifestyle, treatments, and complications. The study collects detailed information for each pregnancy and implantation attempt to help identify factors contributing to miscarriage and implantation failure. Throughout an average follow-up of five years, researchers will describe the clinical characteristics, tests, and care these women receive. They will also track the recurrence of pregnancy losses and implantation failures, compare responses to immunomodulatory treatments, and assess the psychological and lifestyle impacts on pregnancy. This ongoing observation helps deepen understanding of early pregnancy loss and supports better management in the future.

Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors