Hydroxychloroquine in recurrent pregnancy loss: data from a French prospective multicenter registry.
Amandine Dernoncourt, Kaies Hedhli, Noémie Abisror...
https://pubmed.ncbi.nlm.nih.gov/38942601Actively Recruiting
Age: 18Years - 50Years
FEMALE
ID05557201
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-12-19
700
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating women who experience unexplained repeated early miscarriages or recurrent implantation failures. This study focuses on women aged 18 to 50 who have had at least three early pregnancy losses before 14 weeks or three failed embryo transfers. The research aims to better understand the causes of these pregnancy challenges, including possible immune system problems and genetic factors, by following patients over several years. Participants are observed as part of their routine medical care in internal medicine or obstetrics-gynecology. On the day they join the study, their medical and pregnancy histories are reviewed, including lifestyle, treatments, and complications. The study collects detailed information for each pregnancy and implantation attempt to help identify factors contributing to miscarriage and implantation failure. Throughout an average follow-up of five years, researchers will describe the clinical characteristics, tests, and care these women receive. They will also track the recurrence of pregnancy losses and implantation failures, compare responses to immunomodulatory treatments, and assess the psychological and lifestyle impacts on pregnancy. This ongoing observation helps deepen understanding of early pregnancy loss and supports better management in the future.
CONDITIONS
Brief Title
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
Who Can Participate
Age: 18Years - 50Years
FEMALE
Eligibility Criteria
You may qualify if you...
- Age 18 to 50 years
- History of at least 3 early pregnancy losses before 14 weeks of gestation and/or at least 3 implantation failures
- Patients who have been informed and have not objected to participating in the study
- Patients covered by a social security system
You will not qualify if you...
- Patients who do not agree to the use of their data
- Patients on AME
- Patients under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for medical history review and data collection
Long-term Monitoring
Duration - Up to 5 years
Participants who undergo routine care are observed to collect data on pregnancy outcomes, medical care, and lifestyle factors over time.
Visits as part of routine healthcare; frequency varies depending on participant's care
Trial Site Locations
Total: 1 location
1
Internal medicine department, hospital Saint Antoine
Paris, France, 75012
Actively Recruiting
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Research Team
A
Arsene MEKINIAN, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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