Study of Gum Disease and Oral Bacteria in Women With Repeated Miscarriages

What this Trial Is About

Researchers are examining the relationship between periodontal disease, oral microbiota, and repeated miscarriages in women. This observational pilot study focuses on women who have experienced at least three miscarriages and aims to understand how oral health and bacterial presence may be linked to miscarriage risk. The study is conducted at Toulouse University Hospital and involves routine dental assessments and sample collections. Participants will undergo a complete oral clinical and radiological examination, including assessments of dental caries, periodontal, mucosal, and functional status. Samples of saliva and subgingival plaque will be collected during routine dental check-ups using sterile methods. The study also includes gathering information about personal and family periodontal history, stress levels, oral hygiene habits, and other risk factors through interviews and clinical evaluations. Women taking part will provide saliva samples by holding saliva in the mouth for one minute and subgingival plaque samples collected with sterile paper points placed in periodontal sulci. Researchers will analyze bacterial content, focusing on Porphyromonas gingivalis and overall microbiological composition. The study includes interviews, clinical and radiological examinations, and assessment of periodontal problems. Participants oral health status and microbiota will be studied cross-sectionally during their routine dental visits.

PERIodontal Disease, Microbiota and Miscarriage