Enhancing cardiovascular risk prediction through AI-enabled calcium-omics.
Ammar Hoori, Sadeer Al-Kindi, Tao Hu...
https://pubmed.ncbi.nlm.nih.gov/38750142/Actively Recruiting
Led by University Hospitals Cleveland Medical Center · Updated on 2025-07-18
77000
Participants Needed
1
Research Sites
104 weeks
Total Duration
Researchers are investigating the impact of a no-charge calcium score screening program on cardiovascular disease risk assessment and related medical practices. Cardiovascular disease prevention often relies on risk scores to guide treatment, but recent reviews show uncertainty about their effectiveness. Coronary artery calcium CAC scoring is a strong risk marker, yet its use is limited due to cost and reimbursement barriers. This study explores whether offering CAC scans for free increases use and affects physician decisions. The study compares two groups of patients undergoing CAC screening one group receiving the test at a low charge of 99, and another group receiving the test at no cost. University Hospitals began providing the no-charge CAC test in 2017 to improve access. The study observes how these pricing differences influence downstream medical decisions such as statin prescriptions and further testing. Participants receive a CAC CT scan and are then monitored for one year to track outcomes including statin prescriptions, non-invasive and invasive coronary ischemia testing, and coronary revascularization procedures. The study includes adults aged 18 to 100 who had a CAC scan at University Hospitals from January 2014 onward. Researchers evaluate how the cost of CAC testing affects screening uptake and subsequent cardiovascular care over the study period.
CONDITIONS
Community Benefit of No-charge Calcium Score Screening Program
S
Sadeer Al-Kindi, M.D.
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University Hospitals Cleveland Medical Center
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo a Coronary Artery Calcium (CAC) CT scan to assess cardiovascular disease risk.
1 visit (in-person)
Duration - 1 year
Participants are observed for up to 1 year following the CAC scan to monitor statin prescription and cardiovascular testing outcomes.
Follow-up assessments over 1 year
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/37664409/University Hospitals Cleveland Medical Center
Lead Sponsor