Comparing Acetaminophen, NSAIDs, and Trypsin-Chymotrypsin Plus Acetaminophen for Pain Relief After Single-Visit Root Canal Treatment in Adults with Symptomatic Irreversible Pulpitis

What this Trial Is About

Researchers are conducting a randomized, single-blind clinical trial to compare the effects of acetaminophen, nonsteroidal anti-inflammatory drugs NSAIDs, and a combination of trypsin-chymotrypsin plus acetaminophen on pain after single-visit root canal treatment for patients with symptomatic irreversible pulpitis. The study follows established guidelines and enrolls adults aged 18 to 60 who meet specific dental and health criteria. Participants will be selected based on clinical tests including digital radiographs and pulp sensitivity. After enrollment and consent, participants undergo a standardized root canal procedure with anesthesia, isolation, canal shaping, and obturation using rotary files and sealers. Following the procedure, participants receive one of three treatments acetaminophen 500 mg three times daily after meals for 3 days, NSAIDs 600 mg three times daily one hour before meals for 3 days, or a combination of acetaminophen and trypsin-chymotrypsin orally three times daily for 3 days. Pain intensity is measured using a visual analog scale VAS at 6, 12, 24, 48, and 72 hours after treatment. Participants return for follow-up visits at these specific timepoints to report pain levels, which are recorded in data forms. Researchers assess pain relief effectiveness using the VAS scores over the 3-day period. The trial is conducted at a single center with careful monitoring of patient responses and adherence. The entire study concludes by December 2026, and participants safety and data accuracy are maintained throughout.

Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment