Report from the American Society of Transplantation on frailty in solid organ transplantation.
Jon Kobashigawa, Darshana Dadhania, Sangeeta Bhorade...
https://pubmed.ncbi.nlm.nih.gov/30506632Actively Recruiting
Age: 60Years +
All Genders
ID06104696
Comprehensive Geriatric Assessment in Kidney Transplantation
Led by Institute for Clinical and Experimental Medicine · Updated on 2023-10-27
1000
Participants Needed
1
Research Sites
782 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to analyze comprehensive geriatric assessments and monitor functional status changes in older adults who are candidates or recipients of kidney transplants. It focuses on patients aged 60 years and older, recognizing that functional and mental status can influence transplant outcomes. The study evaluates frailty syndrome, depressive symptoms, and transplant acceptance and outcomes in this population. Participants undergo functional geriatric assessments using standardized tests to examine physical and mental health. Based on these assessments, participants are categorized as non-frail, pre-frail, or frail. This observational study tracks these groups over a 20-year period, from 2020 to 2040, to observe how their functional status affects transplant listing, transplantation, graft and patient survival, and related adverse events. During the study, researchers collect data on frailty syndrome using the Fried frailty phenotype, depressive symptoms with the GDS scale, and outcomes related to kidney transplantation. Functional status is regularly evaluated through comprehensive geriatric assessments. The study helps understand the impact of pre-transplant health on post-transplant recovery and quality of life, with ongoing monitoring throughout the long-term follow-up period.
CONDITIONS
Brief Title
Comprehensive Geriatric Assessment in Kidney Transplantation
Who Can Participate
Age: 60Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Kidney transplant candidates aged 60 years or older
- Kidney transplant recipients aged 60 years or older
You will not qualify if you...
- Kidney transplant candidates younger than 60 years
- Kidney transplant recipients younger than 60 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 20 years
Participants undergo a comprehensive geriatric assessment to evaluate physical and mental status using standardized tests.
Periodic assessments depending on transplant status
Long-term Monitoring
Duration - 20 years
Participants who are kidney transplant candidates or recipients are observed for changes in functional status, frailty syndrome, transplant acceptance, and outcomes.
Ongoing follow-up visits over the study period
Trial Site Locations
Total: 1 location
1
Department of Nephrology Transplant Centre IKEM
Prague, Czechia, 140 21
Actively Recruiting
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Research Team
S
Silvie Rajnochova Bloudickova, MD,PhD
H
Hana Vankova, MD,PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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Published Research Related To This Trial
The geriatric management of frailty as paradigm of "The end of the disease era".
Matteo Cesari, Emanuele Marzetti, Ulrich Thiem...
https://pubmed.ncbi.nlm.nih.gov/26997416Comprehensive geriatric assessment: a meta-analysis of controlled trials.
A E Stuck, A L Siu, G D Wieland...
https://pubmed.ncbi.nlm.nih.gov/8105269Frailty and Access to Kidney Transplantation.
Christine E Haugen, Nadia M Chu, Hao Ying...
https://pubmed.ncbi.nlm.nih.gov/30890577Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report.
Gill Turner, Andrew Clegg, British Geriatrics Society...
https://pubmed.ncbi.nlm.nih.gov/25336440