Phototherapy

Pain is described as an unpleasant sensory and emotional experience linked to actual or potential tissue damage. This research evaluates whether a single session of Low-Level Laser Therapy (LLLT), a safe and noninvasive treatment with pain-relief and anti-inflammatory effects, can produce immediate changes in pain threshold and pain tolerance in healthy adults. This study focuses on acute nociceptive pain, common in musculoskeletal conditions, and aims to understand LLLT's immediate impact compared to a sham treatment. Participants will be randomly assigned to receive either active LLLT or a sham laser procedure. The active treatment uses a 904 nm wavelength laser applied to three points near the medial epicondyle for a total of 6 minutes, delivering a set energy dose. The sham group undergoes the same procedure without actual laser emission to control for placebo effects. Both groups and the researcher wear safety eyewear during the process. During the study, researchers will measure electrical pain threshold and pain tolerance before and immediately after the intervention. Participants are healthy adults aged 18 to 35 without chronic medical conditions or pain. The trial includes monitoring for safety and adherence to protocols. The total participation involves a single session assessing immediate effects, with no long-term follow-up described.

Researchers are evaluating the safety and effectiveness of photodisinfection therapy (PDT) using the Steriwave14 ND System compared to a control swabbing with a photosensitizer formulation in patients undergoing nasal surgery. This pilot trial aims to reduce the use of antibiotics for presumed surgical site infections (SSI) by eliminating harmful bacteria in the nasal passages before surgery. The study also investigates how well nasal decolonisation removes Staphylococcus aureus and other microbes from the nose, which could help prevent infections after surgery. Participants will be randomly assigned to either receive nasal PDT, which involves two applications of a photosensitizer solution containing methylene blue and chlorhexidine followed by light therapy, or to a control group where their noses are swabbed twice with the photosensitizer solution without light exposure. The PDT treatment is administered in two two-minute cycles before surgery using a CE-marked device and disposable applicators. The control group undergoes the swabbing procedure only. All patients will receive standard post-operative care and wound follow-up according to their surgery type. Before treatment, nasal swabs and flexible nasendoscopy will be done to measure bacterial colonization and inflammation. Participants will have repeat swabs and endoscopy about two weeks after surgery, and a telephone follow-up at 30 days to check antibiotic use and signs of infection. Researchers will assess antibiotic usage, incidence of SSI, nasal bacterial cultures, and inflammation scores. The total follow-up period is 30 days, during which any post-operative interventions will be documented to evaluate the therapy's safety and effectiveness.

Researchers are evaluating whether blue light (BL) photobiomodulation can improve healing of donor site wounds in adult patients with intermediate or deep burn injuries treated surgically. The study aims to find out if adding BL therapy to standard care reduces healing time, improves wound conditions, reduces pain and infection signs, is safe, and enhances long-term scar quality. Burn injuries often require skin grafting, and donor sites can have complications that affect healing and patient comfort. Participants will receive standard wound care on both donor sites, with one site also receiving weekly BL therapy using a medical device for 60 seconds per session over 3-4 weeks. The donor site on the right side will get BL plus standard care, while the left side will receive only standard care. This intra-patient controlled design allows direct comparison of healing between treated and untreated areas within the same patient. During the treatment period, participants will have weekly clinical evaluations including wound observation, pain assessments, skin swabs for infection, and photographic documentation. After complete healing, follow-up visits at 1 and 3 months will assess scar quality and check for late side effects. Safety monitoring will record any adverse reactions related to the blue light treatment throughout the study. The total study duration per participant spans about 4-5 weeks of treatment plus follow-up.

About 50% of full-term newborns and 80% of premature infants develop jaundice which is due to hyperbilirubinemia. In the majority of cases, jaundice disappears naturally without treatment within three weeks of birth, but the bilirubin level may remain too high, which can lead to a serious neurological disease: kernicterus. To avoid this, a therapeutic management must be instituted, and in some cases, one or more phototherapy sessions (PT) may be prescribed. The aim of this trial is to evaluate the safety and level of satisfaction of parents and healthcare team with one innovative device for phototherapy BUBOLight® included two removable strips of luminous textile incorporating optical fibers. 10 newborns requiring phototherapy, will be illuminated during four hours in one session of PT Bilirubin levels is taken at the start of phototherapy H0 and Controls are made at H+6 hours.

Skin rejuvenation aims to improve the signs of skin aging, which involve changes in the skin's layers including reduced collagen leading to thinner skin, laxity, and wrinkles. This trial evaluates and compares two types of laser therapies, fractional CO₂ laser and long-pulsed 1064-nm Nd:YAG laser, both used to stimulate collagen production and improve skin condition. The goal is to assess their effects on dermal thickness, skin elasticity, wrinkles, and overall aesthetic improvement in adults aged 30 to 59 with moderate skin aging.

Researchers are evaluating two different treatments for women who have had persistent low-grade cervical lesions caused by high-risk HPV infection for more than one year. The study compares 5-aminolevulinic acid (5-ALA) photodynamic therapy with CO2 laser treatment to determine which approach may better reduce or eliminate these cervical lesions. This non-randomized controlled trial focuses on women aged 18 to 65 years with confirmed high-risk HPV-related lesions. Participants receive either 5-ALA photodynamic therapy, which involves applying a special cervical gel followed by 25 minutes of laser light exposure repeated three times, or CO2 laser therapy, which removes the cervical lesions in a single session by ablating tissue to a specific depth and width. Both treatments are designed to target persistent low-grade cervical lesions associated with high-risk HPV infection. During the study, women will be monitored for changes in their cervical lesions, with the main outcome measured six months after the last photodynamic therapy session or the CO2 laser treatment. Researchers will also check for any adverse effects six months following CO2 laser therapy. Participants will undergo examinations and follow-up visits as part of the treatment and assessment process, which continues until the study ends in June 2025.

This research aims to compare how different laser wavelengths (808 nm, 980 nm, and 1064 nm) affect nerve healing in patients with Bell's palsy, a condition causing facial paralysis and movement problems. By studying these laser treatments, researchers hope to improve clinical care, rehabilitation methods, and quality of life for people with this nerve disorder. Participants are randomly assigned to one of four groups: a sham laser device group, a Low-Level Laser Therapy group, a gallium arsenide diode laser group, or a high-intensity laser treatment group. Each group receives 18 treatment sessions over six weeks, with three sessions each week. All participants also receive facial muscle massage and exercises to support nerve recovery. During the study, researchers will assess the facial nerve function using compound motor action potential tests at the start and after six weeks of treatment. Other assessments include facial disability scoring and monitoring of therapy sessions. The total study period includes the six-week treatment phase, with safety and progress tracked throughout.

This research aims to determine how bathing affects physiological measures such as heart rate, body temperature, oxygen levels, skin condition, bilirubin levels, and comfort in newborn infants receiving phototherapy for jaundice. Phototherapy is the common treatment for neonatal jaundice, which occurs frequently in newborns and can lead to serious complications if untreated. The study explores whether bathing before phototherapy can reduce side effects like skin rashes and improve infant comfort. The study compares two groups of newborns: those who receive a bathtub bath before phototherapy and those who receive standard care without additional bathing. Phototherapy treatment involves exposing infants to light to lower bilirubin in the blood. The bathing method studied involves using a baby bathtub and baby shampoo. The experimental group gets the bath before starting phototherapy, while the control group follows routine care without extra intervention. Participants will be monitored with multiple assessments including heart rate, respiratory rate, body temperature, oxygen saturation, skin moisture, and skin condition scores at several time points before and after bathing or phototherapy treatment. Bilirubin levels will be measured before treatment and 24 hours after phototherapy begins. Comfort levels will also be evaluated at set intervals. The study runs from hospitalization through six hours post-intervention, with detailed physiological and skin condition tracking to assess the effects of bathing on infants receiving phototherapy.

Fallopian tube obstruction is a common health issue affecting many women and can lead to infertility and other reproductive problems. Researchers are studying laser acupoint therapy as a possible treatment to improve the function of the fallopian tubes by using focused laser light directed at specific points linked to reproductive health. This noninvasive and painless therapy may offer benefits over traditional acupuncture by activating the body's energy pathways to support healing. Participants in this study will be randomly assigned to one of two groups. One group will receive laser acupoint therapy combined with standard care, while the other group will receive a placebo laser acupoint therapy along with standard care. The treatment aims to assess the effect of laser acupoint therapy on fallopian tube obstruction, with no blinding involved. The study starts with treatment and includes follow-up assessments 3 months after treatment. Women who join the study will undergo evaluations including tests to measure tubal patency, anti-Müllerian hormone levels, and pregnancy status three months after treatment. Researchers will monitor these outcomes to understand the therapy's impact. Participants must be able to attend all scheduled sessions and follow-up visits. The study is led by Kafrelsheikh University and runs from April 2025 to April 2026.

Researchers are evaluating two treatment methods for pilonidal sinus disease, a common condition affecting young adults that causes discomfort and time off work. The study compares laser treatment alone to laser treatment combined with crystallized phenol application to see if adding phenol can speed up healing and improve patient outcomes. This is a prospective randomized controlled clinical trial conducted at a training and research hospital. Participants will be randomly assigned to one of two groups: one receiving laser treatment only using the SiLaC (Sinus Laser Closure) technique under local anesthesia, and the other receiving combined treatment with phenol application followed by laser treatment. Both procedures are minimally invasive, performed as day surgeries with local anesthesia, and patients receive standard post-operative wound care before being discharged the same day. During the study, participants will have a preoperative assessment and follow-up visits at 2 weeks, 4 weeks, and 3 months. Researchers will evaluate healing through clinical examinations for epithelialization, measure pain levels using a visual scale, assess quality of life with questionnaires, and track time to return to daily activities. The primary outcome is the time to complete epithelialization, with additional monitoring of pain, complications, patient satisfaction, and quality of life over three months.