Phototherapy

This research evaluates nasal photodisinfection therapy PDT using the Steriwave123 ND System compared to a control group receiving only a photosensitizer formulation in patients undergoing nasal surgery. The study aims to assess the safety and effectiveness of PDT in reducing post-operative complications, especially the need for antibiotics due to surgical site infections. It focuses on patients scheduled for elective nasal surgeries and examines bacterial colonization and mucosal inflammation before and after treatment. Participants are randomly assigned to either receive nasal PDT, involving two applications of a photosensitizer solution activated by light, or control treatment with two swabs of the photosensitizer solution without light activation. Both groups undergo nasal swab cultures and flexible nasendoscopy to assess bacterial presence and inflammation before treatment and about two weeks after surgery. Standard post-operative care is provided to all patients. During the study, participants will have a baseline nasal culture and endoscopic evaluation before surgery, a follow-up in-person review around two weeks after surgery to assess antibiotic use and surgical site infections, and a telephone follow-up at 30 days to monitor antibiotic use and any adverse events. The study measures antibiotic usage, incidence of surgical site infection, nasal bacterial colonization, and mucosal inflammation using specific scoring methods over 30 days following surgery.

Researchers are evaluating whether blue light BL photobiomodulation can improve healing of donor site wounds in adult patients with intermediate or deep burn injuries treated surgically. The study aims to find out if adding BL therapy to standard care reduces healing time, improves wound conditions, reduces pain and infection signs, is safe, and enhances long-term scar quality. Burn injuries often require skin grafting, and donor sites can have complications that affect healing and patient comfort. Participants will receive standard wound care on both donor sites, with one site also receiving weekly BL therapy using a medical device for 60 seconds per session over 3-4 weeks. The donor site on the right side will get BL plus standard care, while the left side will receive only standard care. This intra-patient controlled design allows direct comparison of healing between treated and untreated areas within the same patient. During the treatment period, participants will have weekly clinical evaluations including wound observation, pain assessments, skin swabs for infection, and photographic documentation. After complete healing, follow-up visits at 1 and 3 months will assess scar quality and check for late side effects. Safety monitoring will record any adverse reactions related to the blue light treatment throughout the study. The total study duration per participant spans about 4-5 weeks of treatment plus follow-up.

Neonatal jaundice affects about half of full-term newborns and up to 80% of premature infants, caused by high bilirubin levels in the blood. While jaundice often resolves naturally within three weeks, elevated bilirubin can lead to serious brain disease called kernicterus. This trial aims to evaluate the safety and satisfaction of parents and healthcare staff using a new phototherapy device called BUBOLight, which uses luminous textile strips with optical fibers to treat newborn jaundice. The study involves 10 newborns requiring phototherapy who will receive one 4-hour session of phototherapy using the BUBOLight device. Bilirubin levels will be measured at the start of treatment and six hours later. The device is being evaluated as a new treatment approach for managing jaundice in newborns. Participants will be monitored for adverse events during and after phototherapy at baseline, 2 hours, and 4 hours. Additional assessments include blood and skin bilirubin levels, newborn pain and discomfort scores, and feedback from parents and healthcare providers about the device. The study is conducted until December 2026, with safety and satisfaction as key outcomes.

Skin rejuvenation aims to improve the signs of skin aging, which involve changes in the skins layers including reduced collagen leading to thinner skin, laxity, and wrinkles. This trial evaluates and compares two types of laser therapies, fractional CO laser and long-pulsed 1064-nm NdYAG laser, both used to stimulate collagen production and improve skin condition. The goal is to assess their effects on dermal thickness, skin elasticity, wrinkles, and overall aesthetic improvement in adults aged 30 to 59 with moderate skin aging.

Researchers are evaluating two different treatments for women who have had persistent low-grade cervical lesions caused by high-risk HPV infection for more than one year. The study compares 5-aminolevulinic acid 5-ALA photodynamic therapy with CO2 laser treatment to determine which approach may better reduce or eliminate these cervical lesions. This non-randomized controlled trial focuses on women aged 18 to 65 years with confirmed high-risk HPV-related lesions. Participants receive either 5-ALA photodynamic therapy, which involves applying a special cervical gel followed by 25 minutes of laser light exposure repeated three times, or CO2 laser therapy, which removes the cervical lesions in a single session by ablating tissue to a specific depth and width. Both treatments are designed to target persistent low-grade cervical lesions associated with high-risk HPV infection. During the study, women will be monitored for changes in their cervical lesions, with the main outcome measured six months after the last photodynamic therapy session or the CO2 laser treatment. Researchers will also check for any adverse effects six months following CO2 laser therapy. Participants will undergo examinations and follow-up visits as part of the treatment and assessment process, which continues until the study ends in June 2025.

Researchers are comparing two methods of crown lengthening, a dental procedure to reshape gums and sometimes bone to expose more of a tooths structure. This procedure is performed for both functional reasons, like preparing a tooth for a crown, and aesthetic reasons, such as improving the smiles appearance. The study evaluates traditional surgical crown lengthening against a less invasive laser-assisted method using the erbiumYAG laser, focusing on periodontal health outcomes. The study involves two groups one receiving the traditional surgical crown lengthening, which includes incisions, flap elevation, bone reshaping, and suturing and the other treated with the erbiumYAG laser that reshapes soft and hard tissues using specific laser settings and tips without flap surgery. The laser group uses a flapless technique, aiming to reduce discomfort and promote faster healing. Both procedures are performed following standard clinical guidelines. Participants will be assessed for postoperative pain shortly after treatment and at three days, as well as periodontal health measures like probing depth at baseline, three months, and six months. Patient satisfaction with the procedure is also measured over time. The study includes follow-up visits for up to six months to monitor outcomes and healing. Overall participation lasts from screening through the follow-up period, with detailed evaluations of pain, tissue healing, and patient experience.

This research aims to compare how different laser wavelengths 808 nm, 980 nm, and 1064 nm affect nerve healing in patients with Bells palsy, a condition causing facial paralysis and movement problems. By studying these laser treatments, researchers hope to improve clinical care, rehabilitation methods, and quality of life for people with this nerve disorder. Participants are randomly assigned to one of four groups a sham laser device group, a Low-Level Laser Therapy group, a gallium arsenide diode laser group, or a high-intensity laser treatment group. Each group receives 18 treatment sessions over six weeks, with three sessions each week. All participants also receive facial muscle massage and exercises to support nerve recovery. During the study, researchers will assess the facial nerve function using compound motor action potential tests at the start and after six weeks of treatment. Other assessments include facial disability scoring and monitoring of therapy sessions. The total study period includes the six-week treatment phase, with safety and progress tracked throughout.

This research aims to determine how bathing affects physiological measures such as heart rate, body temperature, oxygen levels, skin condition, bilirubin levels, and comfort in newborn infants receiving phototherapy for jaundice. Phototherapy is the common treatment for neonatal jaundice, which occurs frequently in newborns and can lead to serious complications if untreated. The study explores whether bathing before phototherapy can reduce side effects like skin rashes and improve infant comfort. The study compares two groups of newborns those who receive a bathtub bath before phototherapy and those who receive standard care without additional bathing. Phototherapy treatment involves exposing infants to light to lower bilirubin in the blood. The bathing method studied involves using a baby bathtub and baby shampoo. The experimental group gets the bath before starting phototherapy, while the control group follows routine care without extra intervention. Participants will be monitored with multiple assessments including heart rate, respiratory rate, body temperature, oxygen saturation, skin moisture, and skin condition scores at several time points before and after bathing or phototherapy treatment. Bilirubin levels will be measured before treatment and 24 hours after phototherapy begins. Comfort levels will also be evaluated at set intervals. The study runs from hospitalization through six hours post-intervention, with detailed physiological and skin condition tracking to assess the effects of bathing on infants receiving phototherapy.

Fallopian tube obstruction is a common health issue affecting many women and can lead to infertility and other reproductive problems. Researchers are studying laser acupoint therapy as a possible treatment to improve the function of the fallopian tubes by using focused laser light directed at specific points linked to reproductive health. This noninvasive and painless therapy may offer benefits over traditional acupuncture by activating the bodys energy pathways to support healing. Participants in this study will be randomly assigned to one of two groups. One group will receive laser acupoint therapy combined with standard care, while the other group will receive a placebo laser acupoint therapy along with standard care. The treatment aims to assess the effect of laser acupoint therapy on fallopian tube obstruction, with no blinding involved. The study starts with treatment and includes follow-up assessments 3 months after treatment. Women who join the study will undergo evaluations including tests to measure tubal patency, anti-Mllerian hormone levels, and pregnancy status three months after treatment. Researchers will monitor these outcomes to understand the therapys impact. Participants must be able to attend all scheduled sessions and follow-up visits. The study is led by Kafrelsheikh University and runs from April 2025 to April 2026.

Researchers are evaluating two treatment methods for pilonidal sinus disease, a common condition affecting young adults that causes discomfort and time off work. The study compares laser treatment alone to laser treatment combined with crystallized phenol application to see if adding phenol can speed up healing and improve patient outcomes. This is a prospective randomized controlled clinical trial conducted at a training and research hospital. Participants will be randomly assigned to one of two groups one receiving laser treatment only using the SiLaC Sinus Laser Closure technique under local anesthesia, and the other receiving combined treatment with phenol application followed by laser treatment. Both procedures are minimally invasive, performed as day surgeries with local anesthesia, and patients receive standard post-operative wound care before being discharged the same day. During the study, participants will have a preoperative assessment and follow-up visits at 2 weeks, 4 weeks, and 3 months. Researchers will evaluate healing through clinical examinations for epithelialization, measure pain levels using a visual scale, assess quality of life with questionnaires, and track time to return to daily activities. The primary outcome is the time to complete epithelialization, with additional monitoring of pain, complications, patient satisfaction, and quality of life over three months.