Confounding Factors of Chronic Endometritis in Women With Reproductive Failure

What this Trial Is About

This research aims to explore the factors that may confuse the diagnosis of chronic endometritis and to evaluate the potential benefits of antibodies that target plasma cells in women experiencing reproductive failure. The study focuses on women who have had repeated miscarriages, failed to conceive after a year, or faced implantation failure during IVF treatments. The study is observational and is conducted at specialized reproductive health clinics. Participants will undergo endometrial sampling during the mid-luteal phase of their menstrual cycle. In natural cycles, urine tests will track the luteinizing hormone surge to time the sampling precisely seven days later. In artificial cycles, estradiol medication is given to prepare the uterus, followed by progesterone supplementation if specific criteria are met. Endometrial samples are collected using a Pipelle sampler during outpatient visits. If chronic endometritis is detected, antibiotics will be administered following hospital guidelines, and a follow-up sample will be taken to assess treatment response. Throughout the study, women will have their plasma cell levels in the endometrium measured using immunohistochemical staining. Researchers will track important outcomes such as live birth rates and compare pregnancy, miscarriage, and implantation rates across groups. The study includes thorough monitoring through histology and microbiology of repeated endometrial samples. Overall participation lasts up to several years, with the primary results expected by the end of 2027 and further comparisons by early 2028.

Confounding Factors of Chronic Endometritis in Women With Reproductive Failure