Actively Recruiting
Constraint-Induced Movement Therapy and Bilateral Training in Chronic Stroke
Led by Zikra Azhar · Updated on 2026-01-30
112
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Stroke often leads to long-term disability, particularly affecting upper limb movement and hand function in the chronic phase, which impacts daily independence and quality of life. This trial compares two rehabilitation approaches, Constraint-Induced Movement Therapy (CIMT) combined with Functional Electrical Stimulation (FES) and Bilateral Training (BT) combined with FES, to evaluate their effects on wrist spasticity and hand function in patients with chronic stroke. The study is a single-blinded randomized controlled trial involving 94 participants. Participants will be randomly assigned to one of two groups. Group A will receive CIMT with FES, where the non-affected arm is restrained to encourage use of the affected arm during task-based activities, with electrical stimulation applied to improve muscle activation and reduce spasticity. Group B will receive Bilateral Training with FES, involving simultaneous use of both arms in symmetrical functional tasks with the same electrical stimulation parameters. Both groups will have therapy sessions three times per week for eight weeks. Throughout the study, participants will be assessed at the start and after eight weeks for wrist spasticity using the Modified Ashworth Scale and for upper limb motor function using the Fugl-Meyer Assessment and the Chedoke Arm and Hand Activity Inventory. The trial aims to provide evidence to help clinicians choose the best rehabilitation strategy for improving hand function and reducing spasticity in chronic stroke patients. Participation will last for the eight-week intervention period with evaluations before and after treatment.
CONDITIONS
Brief Title
Constraint Induced Movement Therapy and Bilateral Training in Chronic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with stroke in chronic phase
- Normal cognition with Mini-Mental State (MMS) score 21 and above
- Both male and female patients included
- Adults aged 18 to 65 years
- Participants with spasticity score of 2 or less on Modified Ashworth Scale (MAS)
You will not qualify if you...
- Patients with acute neurological or musculoskeletal conditions such as Parkinson's disease or multiple sclerosis
- Patients who do not agree to treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants receive therapy sessions involving Constraint-Induced Movement Therapy combined with Functional Electrical Stimulation or Bilateral Training combined with Functional Electrical Stimulation. Therapy is aimed at improving wrist spasticity and hand function through task-oriented and functional activities.
3 sessions per week
Trial Site Locations
Total: 1 location
1
Shadman Medical Center
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
Research Team
Z
Zikra Azhar, MSPTN
M
Montiha Azeem, MSPTN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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