Actively Recruiting
Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Patients With Gastrointestinal Neoplasms
Led by Xuanwu Hospital, Beijing · Updated on 2025-04-03
165
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore differences in blood markers between elderly patients with gastrointestinal tumors who experience postoperative delirium (POD) and those who do not develop long-term postoperative neurocognitive disorders (pNCD). The study focuses on patients aged 65 and above undergoing surgery, tracking how POD relates to subsequent cognitive issues. It is a prospective observational cohort study sponsored by Xuanwu Hospital, Beijing. Participants are elderly patients having surgery for gastrointestinal neoplasms. Before surgery, blood tests and cognitive assessments using the Montreal Cognitive Assessment (MoCA) are performed. Anesthesia and surgery are conducted under routine practices with monitoring of vital signs and surgical details. Post-surgery, patients are assessed for delirium within 7 days using the Confusion Assessment Method (CAM). Those with delirium are followed up at 1 month and 12 months to evaluate cognitive function and determine if pNCD develops. Throughout the study, researchers collect data on serum markers before and after surgery and monitor cognitive changes over time. The main outcome is the difference in blood biomarkers between patients who develop pNCD and those who do not, one month after surgery. The study involves detailed cognitive and delirium assessments and aims to clarify the relationship between POD and pNCD in this elderly surgical population.
CONDITIONS
Brief Title
Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 65 years of age or older who have undergone surgical anesthesia for gastrointestinal neoplasms
- Signed informed consent
You will not qualify if you...
- Unable to complete cognitive function assessment
- Illiteracy, hearing impairment, or visual impairment
- History of epilepsy, depression, schizophrenia, Alzheimer's disease, or other psychiatric and neurological diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo surgical operations with routine anesthetic management and intraoperative monitoring.
1 visit (in-person)
Duration - Up to 7 days post-surgery
Participants are assessed for postoperative delirium using the Confusion Assessment Method within 7 days after surgery, classifying them into POD and non-POD groups.
1 to 7 visits depending on assessment timing
Duration - 1 month and 12 months post-surgery
Participants in the POD group undergo neurocognitive function assessments at 1 month and 12 months after surgery to determine the presence of postoperative neurocognitive disorder (pNCD).
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, China, 100053
Actively Recruiting
Research Team
L
Lei Zhao, Doctor's
M
Manke Luo, Bachelor's
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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