Study on Postoperative Delirium and Long-Term Neurocognitive Disorders in Elderly Patients Undergoing Gastrointestinal Cancer Surgery

What this Trial Is About

This research aims to explore differences in blood markers between elderly patients with gastrointestinal tumors who experience postoperative delirium POD and those who do not develop long-term postoperative neurocognitive disorders pNCD. The study focuses on patients aged 65 and above undergoing surgery, tracking how POD relates to subsequent cognitive issues. It is a prospective observational cohort study sponsored by Xuanwu Hospital, Beijing. Participants are elderly patients having surgery for gastrointestinal neoplasms. Before surgery, blood tests and cognitive assessments using the Montreal Cognitive Assessment MoCA are performed. Anesthesia and surgery are conducted under routine practices with monitoring of vital signs and surgical details. Post-surgery, patients are assessed for delirium within 7 days using the Confusion Assessment Method CAM. Those with delirium are followed up at 1 month and 12 months to evaluate cognitive function and determine if pNCD develops. Throughout the study, researchers collect data on serum markers before and after surgery and monitor cognitive changes over time. The main outcome is the difference in blood biomarkers between patients who develop pNCD and those who do not, one month after surgery. The study involves detailed cognitive and delirium assessments and aims to clarify the relationship between POD and pNCD in this elderly surgical population.

Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms