Study of Blood Markers and Brain Function Changes in Older Adults After Spinal Surgery Looking at Delirium and Long-Term Cognitive Disorders

What this Trial Is About

Researchers are studying elderly patients who have undergone spinal surgery to understand the differences in blood serum markers between those who develop postoperative delirium POD and those who do not. The study specifically focuses on patients aged 65 and older and aims to explore how POD relates to long-term postoperative neurocognitive disorders pNCD. Participants receive standard general anesthesia with endotracheal intubation during their spinal surgery. After surgery, delirium is assessed within 7 days using the Confusion Assessment Method CAM, splitting patients into groups with or without POD. Those with POD are followed up at 1 month and 12 months post-surgery to check for signs of pNCD. Researchers compare serum markers before and after surgery among these groups to investigate correlations. Before surgery, cognitive function is tested using the Montreal Cognitive Assessment MoCA. Blood serum samples are collected and analyzed for changes over time. Participants with POD undergo repeated cognitive assessments and serum tests during follow-up visits. The primary measure is the difference in serum markers one month after surgery between patients with and without pNCD. The study spans from May 2024 to May 2026, with ongoing monitoring and data collection to understand neurocognitive outcomes after spinal surgery in elderly patients.

Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients