Actively Recruiting
Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Spinal Surgery Patients
Led by Xuanwu Hospital, Beijing · Updated on 2025-04-03
165
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying elderly patients who have undergone spinal surgery to understand the differences in blood serum markers between those who develop postoperative delirium (POD) and those who do not. The study specifically focuses on patients aged 65 and older and aims to explore how POD relates to long-term postoperative neurocognitive disorders (pNCD). Participants receive standard general anesthesia with endotracheal intubation during their spinal surgery. After surgery, delirium is assessed within 7 days using the Confusion Assessment Method (CAM), splitting patients into groups with or without POD. Those with POD are followed up at 1 month and 12 months post-surgery to check for signs of pNCD. Researchers compare serum markers before and after surgery among these groups to investigate correlations. Before surgery, cognitive function is tested using the Montreal Cognitive Assessment (MoCA). Blood serum samples are collected and analyzed for changes over time. Participants with POD undergo repeated cognitive assessments and serum tests during follow-up visits. The primary measure is the difference in serum markers one month after surgery between patients with and without pNCD. The study spans from May 2024 to May 2026, with ongoing monitoring and data collection to understand neurocognitive outcomes after spinal surgery in elderly patients.
CONDITIONS
Brief Title
Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 65 years of age or older who have undergone spinal surgery anesthesia
- Signed informed consent
You will not qualify if you...
- Inability to complete cognitive function assessment
- Illiteracy, hearing impairment, or visual impairment
- History of epilepsy, depression, schizophrenia, Alzheimer's disease, or other psychiatric and neurological diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo spinal surgery with routine anesthetic management under general anesthesia.
1 visit (in-person)
Duration - 7 days
Delirium is assessed within 7 days after surgery using the Confusion Assessment Method (CAM) to classify participants into POD and non-POD groups.
1 visit (in-person)
Duration - 12 months
Participants in the POD group undergo neurocognitive function assessments at 1 month and 12 months after surgery to determine the presence of postoperative neurocognitive disorder (pNCD).
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University, Beijing, 100053
Beijing, China
Actively Recruiting
Research Team
L
lei zhao
K
ke cui
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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