Creatine Supplementation and Brain Health.
Hamilton Roschel, Bruno Gualano, Sergej M. Ostojic...
https://pubmed.ncbi.nlm.nih.gov/33578876Actively Recruiting
Led by San Diego State University · Updated on 2025-06-26
20
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to compare concussion recovery between individuals who take creatine supplements and those who do not. The study focuses on measuring the number of days until participants become asymptomatic after a concussion and comparing concussion assessment scores such as symptoms, mental status, neurocognition, balance, motor coordination, and visual performance between the two groups. Participants will be randomly assigned to either a control group that consumes their usual diet without creatine or an intervention group that adds creatine supplementation to their diet. The intervention group will take 5 grams of creatine daily for the first four days after the initial meeting, then 3 grams daily thereafter until they become asymptomatic. The researchers will maintain contact with participants throughout recovery to monitor compliance and assess symptom resolution. During the study, participants will complete several assessments including the Sport Concussion Office Assessment Tool-6, computerized neurocognitive tests (CNS Vital Signs), and a visual assessment (King-Devick). These evaluations will occur at enrollment and once participants are asymptomatic. The team will analyze demographic data, days to symptom resolution, and various concussion-related measures to determine differences between groups. The study may last up to 100 weeks for each participant.
CONDITIONS
Creatine Supplementation in Concussion Recovery
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Complete this quick 3-step screening to check your eligibility
Duration - Up to 72 hours post-injury
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Until asymptomatic (variable duration up to 100 weeks)
Participants will consume their usual diet with or without creatine supplementation until they become asymptomatic. The intervention group takes 5 grams of creatine daily for the first four days, then 3 grams daily thereafter until symptoms resolve. Investigators will remain in contact with participants to monitor compliance and symptom progression.
Contact frequency varies depending on recovery; typically periodic remote check-ins
Duration - 1 day
Once asymptomatic, participants complete detailed concussion assessments including symptom evaluation, computerized neurocognitive tests, and a visual assessment to compare recovery outcomes.
1 assessment visit (in-person) lasting approximately 1.5 hours
Total: 1 location
1
San Diego State University
San Diego, California, United States, 92812
Actively Recruiting
M
Michelle Weber Rawlins, PhD, ATC
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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