American Medical Society for Sports Medicine position statement on concussion in sport.
Kimberly G Harmon, James R Clugston, Katherine Dec...
https://pubmed.ncbi.nlm.nih.gov/30705232/Actively Recruiting
Led by San Diego State University · Updated on 2026-06-18
20
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying concussion recovery by comparing individuals who take creatine supplements with those who do not. The study aims to see if people taking creatine become symptom-free faster after a concussion and if their concussion assessment scores, including symptoms, mental status, balance, motor coordination, and visual performance, are better once they are asymptomatic. The study includes adults aged 18 to 35 who have had a diagnosed concussion within 72 hours. Participants will be randomly assigned to one of two groups one group will consume their usual diet plus 5 grams of creatine daily for the first four days, then 3 grams daily until symptoms resolve the other group will continue their usual diet without creatine. After initial screening and consent, participants will complete symptom checklists and concussion assessments. The research team will maintain contact to monitor compliance and recovery, adjusting frequency based on symptom severity. When participants become asymptomatic, they will undergo detailed assessments including symptom checklists, computerized neurocognitive tests, and visual evaluations. The researchers will analyze time to symptom resolution and various concussion-related scores using statistical tests. Participants may be followed and assessed for up to 100 weeks from injury to gather comprehensive data on recovery and cognitive function.
CONDITIONS
Creatine Supplementation in Concussion Recovery
M
Michelle Weber Rawlins, PhD, ATC
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San Diego State University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Creatine supplementation | Standard post-concussion management (no creatine) | Guideline-recommended concussion management |
|---|---|---|---|
| What is it? | Participants supplement with creatine (a dietary supplement used by some athletes), begun within 72 hours post-concussion, to see whether it influences recovery. | Participants receive usual care and observation after concussion with no additional supplements added. | Guidelines recommend individualized concussion management involving initial rest, gradual resumption of activity, and symptom monitoring with medical oversight. |
| Role in study | Investigational arm studying whether creatine supplementation started soon after concussion affects recovery trajectory. | Randomized comparator arm; represents typical recovery without additional supplementation. | Current-care contextual benchmark, summarizing what is recommended outside the trial per sports medicine and athletic training guidance for post-concussion recovery. |
| Primary use or goal | Test whether creatine supplementation may shorten days to asymptomatic status, improve cognitive or physical function, or influence post-concussion symptoms. | Facilitate natural recovery from concussion with symptom monitoring, but no specific new treatment. | Promote safe and gradual recovery by monitoring symptoms, guiding rest and activity, and reducing risk of complications such as second impact syndrome. |
| How is it given or performed? | Creatine powder is consumed as a dietary supplement, started within 72 hours after concussion and continued per protocol for the duration of the study. | No new supplement or investigational treatment is started. Participants receive observation and care for symptoms as with typical immediate post-concussion management. | Care involves an initial period of rest (24-48 hours), followed by progressive re-introduction of physical and cognitive activity under guidance, symptom tracking, and regular medical oversight to determine readiness to return to activity. |
| Current evidence status | There is ongoing investigation and limited published evidence about creatine supplementation for post-concussion recovery. No established benefit is proven to date. | Ongoing clinical trial; results for post-concussion recovery without any supplement in this age group are not yet established by this trial. | Standard care, including progressive reintroduction of activity with symptom monitoring, is supported by extensive professional consensus and clinical experience, but individual recovery times vary. |
| Important limitations | Benefit for concussion recovery is not yet established; possible variations in dosing, timing, or patient response; safety for all patients post-concussion is not fully described. | May not actively accelerate recovery or prevent prolonged symptoms in some cases; relies on natural course and observation. | While widely recommended, standard care does not guarantee rapid or complete symptom resolution; recovery may still be prolonged for some individuals. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 100 weeks or until asymptomatic
Participants will be randomly assigned to take creatine supplements along with their usual diet or to continue their usual diet without creatine until they become symptom-free. The research team will maintain contact to monitor recovery and compliance.
Regular contact as recovery progresses
Duration - Approximately 1.5 hours for assessment
Once participants become symptom-free, they will complete detailed concussion assessments including symptom checklists, computerized neurocognitive tests, and visual evaluations.
1 assessment visit
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/25232881/San Diego State University
Lead Sponsor