Adverse cerebral effects of anaesthesia on old people.
P D BEDFORD
https://pubmed.ncbi.nlm.nih.gov/13243706Actively Recruiting
Phase 1
Age: 60Years - 80Years
All Genders
ID06702488
The Efficacy of Dexmedetomidine and Magnesium Sulfate in Cognitive Dysfunction in Elderly Patients Undergoing Abdominal Surgery
Led by Fayoum University · Updated on 2024-11-25
58
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of dexmedetomidine and magnesium sulfate on postoperative cognitive dysfunction (POCD) in elderly patients aged 60 to 80 undergoing open abdominal surgery under general anesthesia. POCD is a condition causing changes in thinking and mental functions after surgery, with a higher risk in older adults due to increased sensitivity to anesthetic drugs and other physiological changes. This study also examines the impact of these drugs on serum levels of C-reactive protein (CRP), a marker linked to neuronal degeneration and inflammation. Participants will be randomly assigned to receive either dexmedetomidine or magnesium sulfate during their surgery. The dexmedetomidine group will receive a bolus dose of 0.5 micrograms per kilogram over 10 minutes before anesthesia induction, followed by an infusion at 0.3 micrograms per kilogram per hour until the skin closure. The magnesium sulfate group will receive a loading dose of 20 milligrams per kilogram over 10 minutes before induction, followed by a maintenance dose of 5 milligrams per kilogram per hour until skin closure. During the study, researchers will monitor participants for the incidence of POCD 24 hours after surgery and measure CRP levels to explore their correlation with cognitive changes. Participants will be assessed through clinical evaluations before and after surgery. The study includes careful monitoring of inflammatory markers and neuronal injury proteins to understand the neuroprotective effects of the treatments. Total participation involves the perioperative period with follow-up at 24 hours post-operation.
CONDITIONS
Brief Title
Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics
Who Can Participate
Age: 60Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- ASA physical status I, II, or III
- Patients aged 60 to 80 years
- Undergoing open abdominal surgery under general anesthesia
- Preoperative MoCA score of 26 or higher
You will not qualify if you...
- Elderly patients with preoperative MoCA score below 26
- Surgery lasting more than 4 hours
- Body mass index (BMI) greater than 35 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Duration of surgery up to 4 hours
Participants receive either dexmedetomidine or magnesium sulfate during surgery until skin closure.
1 intraoperative treatment session
Follow-up
Duration - 24 hours postoperative
Participants are assessed for cognitive function and inflammation markers after surgery.
1 visit (in-person) within 24 hours after surgery
Trial Site Locations
Total: 1 location
1
Dexmedetomidine
Al Fayyum, Egypt
Actively Recruiting
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Research Team
M
Mohamed Ahmed Hamed, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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