Actively Recruiting
Diagnosis and Prognosis for Aortic Aneurysm and Dissection in Anzhen Registry Study
Led by Beijing Institute of Heart, Lung and Blood Vessel Diseases · Updated on 2024-06-27
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Lead Sponsor
B
Beijing Luhe Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate biomarkers for the diagnosis and prognosis of aortic aneurysm and aortic dissection. It includes a discovery phase with age- and sex-matched case-control groups for various conditions including aortic dissection, acute myocardial infarction, pulmonary embolism, aortic aneurysm without dissection, and healthy controls. The study also follows patients with confirmed aortic aneurysm and dissection to assess outcomes like mortality. The study has two parts: a retrospective diagnosis phase and a prospective prognosis phase. Patients are enrolled based on clinical suspicion or confirmed diagnosis. Biomarker levels are categorized into thirds for analysis. The primary focus is on all-cause mortality and in-hospital mortality as outcome measures collected from medical records and follow-up visits over an average of 6 months to 2-4 years. Participants undergo medical record reviews and follow-up visits to collect data on diagnosis and prognosis. Researchers monitor survival outcomes and biomarker levels over time. The study involves adults aged 18 to 80 years and tracks patient health status through medical documentation and follow-ups to better understand disease progression and outcomes.
CONDITIONS
Brief Title
Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen(DPANDA) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients referred to surgical service for evaluation and management of aortic dissection (retrospective)
- Patients with initial suspicion of acute aortic dissection enrolled prospectively
- Age between 18 and 80 years
- Both male and female participants
You will not qualify if you...
- Patients who received blood transfusions (packed red blood cells, whole blood, or platelets) less than 10 days before sample collection (retrospective)
- Patients with aortic trauma, pseudo aneurysm, history of heart failure, renal dysfunction, severe pulmonary diseases, or active cancer (retrospective)
- Patients admitted for checkups after surgery (retrospective)
- Patients with little or no suspicion of life-threatening disease (prospective)
- Patients with confirmed acute myocardial infarction, angina, or pulmonary embolism (prospective)
- Patients with symptoms clearly unrelated to aortic dissection, such as pleurisy, pneumonia, or acute abdominal diseases (prospective)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants with suspicion of aortic dissection undergo diagnostic assessments and biomarker sample collection to determine diagnosis.
1 visit (in-person) for sample collection and medical record review
Duration - 2 to 4 years after discharge
Participants are followed for prognosis assessment through medical record review and follow-up visits to evaluate outcomes such as mortality.
Follow-up visits as scheduled over 2 to 4 years
Trial Site Locations
Total: 1 location
1
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
Research Team
Y
Yuan Wang, PhD
X
Xue Wang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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