Investigation of Mnesic Capacities in Patients With a Disorder of Consciousness - MemoDoC

What this Trial Is About

Researchers are investigating the memory abilities of Intensive Care Unit patients who have a Disorder of Consciousness (DoC) caused by severe brain injury. The study aims to understand different types and stages of memory, including perceptual, episodic, and autobiographical memory, to better assess the cognitive profile of these patients. This research addresses the challenge of diagnosing consciousness levels and seeks to improve neurological prognosis and care by detecting memory processes that are not visible through clinical behavior alone. The study uses advanced physiological tools such as high-density electroencephalography (hdEEG) and electrocardiography (ECG) alongside auditory and olfactory stimuli to evaluate memory formation and retrieval in non-communicating patients over two days in the ICU. It includes protocols to assess new memory encoding and long-term retrieval, as well as the investigation of past autobiographical memories. Patients who have regained consciousness will also participate in interviews and neuropsychological tests to explore their subjective experiences and memory function. Participants will undergo physiological recordings, interviews, and cognitive assessments during and after their ICU stay. The study measures brain and bodily responses to stimuli and collects data on memory recovery through follow-up consultations occurring between three and twelve months post-resuscitation. Machine learning techniques will analyze these data to identify memory markers, and group comparisons will explore differences between DoC subtypes and conscious ICU patients. This comprehensive approach aims to improve diagnosis, guide rehabilitation, and deepen understanding of memory and consciousness interplay.

Investigation of Mnesic Capacities in Patients With a Disorder of Consciousness