Actively Recruiting
Down Syndrome, Physical Activity and Sleep Apnea
Led by University Hospital, Grenoble · Updated on 2024-01-17
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying sleep patterns and sleep apnea in people with Down syndrome, focusing on how these sleep disorders develop and affect health. Sleep problems are common in this group, often starting in early childhood, but diagnosis can be delayed. This research aims to better understand sleep characteristics and their causes, especially sleep apnea, which involves multiple body systems. Participants include children, teenagers, and adults with Down syndrome, both with and without sleep disorders. The study observes sleep patterns over several nights and examines related factors such as physical activity, biological markers, cranial structure, and neurobehavioral issues. Assessments take place on specific days and visits, including overnight monitoring and physical activity evaluations. During the study, participants undergo sleep phenotyping over two nights and additional monitoring nights for breathing and autonomic function. Researchers collect biological samples and perform physical activity assessments to explore links with sleep-disordered breathing. The study also considers cranial structure and neurobehavioral factors. Participation lasts up to about 90 days with multiple visits for evaluations and monitoring.
CONDITIONS
Brief Title
Down Syndrome, Physical Activity and Sleep Apnea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Total autosomal trisomy caused by the presence of a third copy (partial or total) of chromosome 21
You will not qualify if you...
- People with abnormal electrocardiographic tracings
- Existence of heart failure or cardiovascular disease, as determined by any abnormalities in cardiovascular adaptations to exercise
- Existence of a declared or uncontrolled progressive disease
- Pregnant or breast-feeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 nights
Participants undergo phenotyping of sleep characteristics with a focus on sleep apnea syndrome, including sleep-disordered breathing assessments and evaluations of physical activity and biological markers.
1 to 3 overnight visits
Duration - Up to 90 days
Participants are observed for up to 90 days to assess sleep-disordered breathing in relation to physical activity and neurobehavioral factors.
Visits as scheduled over the monitoring period
Trial Site Locations
Total: 1 location
1
Chu Grenoble Alpes
La Tronche, France, 38043
Actively Recruiting
Research Team
V
Veronique BRICOUT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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