Effects of Exercise and Liraglutide on Blood Vessel Function and Insulin Response in Adults with Type 2 Diabetes

What this Trial Is About

Researchers are investigating how exercise training, liraglutide treatment, or a combination of both affect blood flow in small vessels, large blood vessel function, and insulin action in adults with Type 2 diabetes. The study aims to see if activating the GLP-1 receptor with liraglutide or exercising can improve muscle blood flow, promote new blood vessel growth, and enhance insulin response, potentially leading to better oxygen and nutrient delivery and higher exercise tolerance. Participants will be randomly assigned to one of three groups exercise training alone, liraglutide treatment alone, or both exercise training plus liraglutide. Each group will undergo 16 weeks of their assigned intervention. The treatments involve sustained activation of the GLP-1 receptor or exercise training to evaluate their effects on vascular and metabolic function. During the study, participants will be assessed at the start and after 16 weeks of intervention. Researchers will measure changes in microvascular blood volume as the primary outcome. Secondary outcomes include various measures of blood vessel function and insulin sensitivity. The study includes monitoring vascular health and metabolic responses to understand the benefits of the interventions in adults aged 21 to 60 with Type 2 diabetes.

Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)