Actively Recruiting
UK Imaging Diabetes Study Seeing Diabetes Clearly
Led by Perspectum · Updated on 2025-12-05
1000
Participants Needed
12
Research Sites
N/A
Total Duration
On this page
Sponsors
P
Perspectum
Lead Sponsor
M
Moorfields Eye Hospital NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, observational study to assess the health of multiple organs in adults with type 2 diabetes who have no history of cardiovascular disease. The goal is to understand if detailed MRI measurements can help predict future clinical events over a 5-year period. Participants include adults diagnosed with type 2 diabetes, especially those diagnosed within the last three years. Participants will undergo no changes to their standard medical care. The study involves two main visits within one month the first includes body measurements and collection of blood and urine samples for routine diabetes checks, and the second involves a multi-organ, multiparametric MRI scan. Data from these visits, along with access to medical records, will be used to monitor disease progression and predict outcomes over 1, 3, and 5 years. Throughout the 5-year study, researchers will collect MRI metrics, clinical outcomes, and lab samples to evaluate diabetes progression. Participants consent to access their hospital and mortality records for event tracking. The primary outcome is the rate of major cardiovascular events three years after the baseline MRI. Secondary outcomes include kidney, eye, liver, cancer, and mortality events assessed at 1, 3, and 5 years. The study requires only a short period of active participation, with long-term follow-up through record review.
CONDITIONS
Brief Title
UK Imaging Diabetes Study Seeing Diabetes Clearly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female at least 18 years of age
- Diagnosed with type 2 diabetes, with or without diabetic retinopathy
- Willing and able to give informed consent for participation
You will not qualify if you...
- History of cardiovascular events in the past 12 months, including myocardial infarction, ischemic stroke, unstable angina, heart surgery, or transient ischemic attack
- Contraindications to MRI such as pregnancy, extensive tattoos, pacemaker, shrapnel injury, or severe claustrophobia
- Known autoimmune hepatitis, viral hepatitis, Wilson's disease, or significant structural kidney abnormalities
- Known alcohol dependency
- Any other significant disease or disorder that may put the participant at risk or affect participation as judged by the investigator
Research Team
S
Soubera Rymall, MSc
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