Actively Recruiting
UK Imaging Diabetes Study Seeing Diabetes Clearly
Led by Perspectum · Updated on 2025-12-05
1000
Participants Needed
12
Research Sites
N/A
Total Duration
On this page
Sponsors
P
Perspectum
Lead Sponsor
M
Moorfields Eye Hospital NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, observational study to assess the health of multiple organs in adults with type 2 diabetes who have no history of cardiovascular disease. The goal is to understand if detailed MRI measurements can help predict future clinical events over a 5-year period. Participants include adults diagnosed with type 2 diabetes, especially those diagnosed within the last three years. Participants will undergo no changes to their standard medical care. The study involves two main visits within one month: the first includes body measurements and collection of blood and urine samples for routine diabetes checks, and the second involves a multi-organ, multiparametric MRI scan. Data from these visits, along with access to medical records, will be used to monitor disease progression and predict outcomes over 1, 3, and 5 years. Throughout the 5-year study, researchers will collect MRI metrics, clinical outcomes, and lab samples to evaluate diabetes progression. Participants consent to access their hospital and mortality records for event tracking. The primary outcome is the rate of major cardiovascular events three years after the baseline MRI. Secondary outcomes include kidney, eye, liver, cancer, and mortality events assessed at 1, 3, and 5 years. The study requires only a short period of active participation, with long-term follow-up through record review.
CONDITIONS
Brief Title
UK Imaging Diabetes Study Seeing Diabetes Clearly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female at least 18 years of age
- Diagnosed with type 2 diabetes, with or without diabetic retinopathy
- Willing and able to give informed consent for participation
You will not qualify if you...
- History of cardiovascular events in the past 12 months, including myocardial infarction, ischemic stroke, unstable angina, heart surgery, or transient ischemic attack
- Contraindications to MRI such as pregnancy, extensive tattoos, pacemaker, shrapnel injury, or severe claustrophobia
- Known autoimmune hepatitis, viral hepatitis, Wilson's disease, or significant structural kidney abnormalities
- Known alcohol dependency
- Any other significant disease or disorder that may put the participant at risk or affect participation as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month
Participants complete baseline assessments including anthropometric measurements, blood and urine samples, and a multi-organ MRI scan to collect data on type 2 diabetes and organ health.
2 visits (in-person) within 28 days of screening
Duration - 5 years
Participants' medical records are accessed periodically to monitor health outcomes related to diabetes over 5 years following baseline assessments.
Medical record reviews at 1, 3, and 5 years after baseline
Trial Site Locations
Total: 12 locations
1
Woodlands Medical Centre
Didcot, Oxfordshire, United Kingdom, OX11 0BB
Actively Recruiting
2
Eynsham Medical Centre
Eynsham, Oxfordshire, United Kingdom, OX29 4QB
Actively Recruiting
3
White Horse Medical Practice
Farringdon, Oxfordshire, United Kingdom, SN7 7YU
Actively Recruiting
4
Windrush Medical Practice
Witney, Oxfordshire, United Kingdom, OX26 6JS
Actively Recruiting
5
The House Partnership
Redhill, Surrey, United Kingdom, RH1 1EB
Actively Recruiting
6
Swansea Bay University Health Board
Baglan, Swansea, United Kingdom, SA12 7BR
Not Yet Recruiting
7
University Hospitals of Liverpool Group
Liverpool, United Kingdom, L9 7AL
Actively Recruiting
8
Moorfields Eye Hospital NHS Foundation Trust
London, United Kingdom
Enrolling by Invitation
9
The Manor Group
Oxford, United Kingdom, OX3 9BP
Actively Recruiting
10
Hedena Health
Oxford, United Kingdom, OX3 9JA
Actively Recruiting
11
St Bartholomew and Hollow Way Medical Practice
Oxford, United Kingdom, OX4 1XB
Actively Recruiting
12
Oxford Community Diagnostic centre
Oxford, United Kingdom, OX42LL
Actively Recruiting
Research Team
S
Soubera Rymall, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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