Study of Daily Fixation Training with Blue vs Red Light Targets to Reduce Light Sensitivity After Traumatic Brain Injury in Adults

What this Trial Is About

Researchers are investigating how daily fixation training using colored light targets affects light sensitivity in people who have had a traumatic brain injury TBI. Many people with TBI develop intolerance to ambient light, but it is unclear why and how best to treat this symptom. This clinical trial aims to compare the effects of blue light versus red light targets in reducing light intolerance and altering pupil responses in individuals with chronic TBI-related photophobia. Participants will use an at-home fixation device for daily 20-minute sessions over 12 weeks, starting with either a blue or red light target. After the first 12 weeks, participants will switch to the other colored light target for another 12 weeks. This crossover design allows comparison of the two light colors. Masked examiners will evaluate vision and eye function every 6 weeks during the study, including reading ability, pupil responses, side vision, eye alignment, and focusing ability. Throughout the study, participants will complete symptom surveys and undergo several vision tests to assess the effect of the training. The primary outcome measured is the change in pupil responses from baseline to the end of each 12-week training period. Secondary outcomes include symptom changes and various measures of visual function. The total participation time covers both 12-week treatment periods with evaluations at regular intervals, aiming to understand if blue light fixation training offers greater benefits than red light for TBI-associated light sensitivity.

Effect of Fixation Training With Colored Light Targets on Traumatic Brain Injury-Associated Photophobia