Actively Recruiting
Effect of Hyperoxygenated Environment on Maximal Muscle Strength in the Mid-thigh Pull Test - a Blinded, Randomized, Sham-Controlled Crossover Study
Led by Assaf-Harofeh Medical Center · Updated on 2026-04-30
48
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how a hyperoxygenated environment affects maximal muscle strength during the Mid-thigh Pull Task. The study focuses on healthy, physically active adults aged 18 to 45 who have recent resistance training experience. It explores whether increased oxygen availability in muscle tissue, provided by hyperbaric oxygen therapy, influences the oxidative energy system's role in peak force production, which is usually considered minimal during high-intensity efforts. Participants will undergo two different protocols in a randomized, blinded crossover design. One protocol involves a 60-minute session inhaling 100% oxygen at 2 atmosphere absolute (ATA) pressure in a hyperbaric chamber. The other is a sham session with normal air (21% oxygen) at a slightly elevated but near normal pressure. Both sessions include isometric mid-thigh pull tests performed after 15 minutes at the target pressure to measure peak muscle force, with three attempts and rest periods between tries. During the study, participants will have baseline and follow-up measurements of maximal static muscle force using the isometric mid-thigh pull test in the hyperbaric chamber. Approximately four weeks after the first visit, they will switch to the opposite intervention and repeat the tests. The study will monitor muscle strength changes under different oxygen conditions and assess recovery between attempts. Overall participation includes two sessions spaced weeks apart, with careful control of oxygen exposure and pressure conditions.
CONDITIONS
Brief Title
Effect of Hyperoxygenated Environment on Maximal Muscle Strength
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy
- Ages 18-45 years
- Physically active with recent resistance training experience of at least six months, training 3 or more times per week
- Willing and able to read, understand, and sign informed consent
You will not qualify if you...
- Unable to attend scheduled clinic visits or comply with the study protocol
- Active malignancy
- Active smokers
- Previous hyperbaric chamber treatment before enrollment
- Chest conditions incompatible with pressure changes
- Major orthopedic injury within the past 3 months
- Inner ear disease
- Lung pathology
- Claustrophobia
- Previous neurologic conditions such as epilepsy, brain tumors, or neurosurgery
- Comorbidities and medications that exclude participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day per session with approximately 4 weeks between sessions
Participants undergo a single session of hyperbaric oxygen therapy or a sham procedure. During the session, participants breathe oxygen at specified pressures and perform isometric mid-thigh pull tests to measure maximal muscle strength.
2 visits (in-person), one for each intervention session
Trial Site Locations
Total: 1 location
1
The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center
Zrifin, Israel
Actively Recruiting
Research Team
E
Eldad mr Yaakobi
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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