Conceptual model of CKD: applications and implications.
Andrew S Levey, Lesley A Stevens, Josef Coresh
https://pubmed.ncbi.nlm.nih.gov/19231760Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05418647
Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time: A Prospective Randomized Clinical Trial
Led by Alexandria University · Updated on 2025-02-11
40
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research evaluates the impact of different sodium levels in dialysate on the time it takes patients to recover after hemodialysis. It focuses on patients with chronic kidney disease undergoing long-term hemodialysis, a group known to suffer frequent fatigue that affects their quality of life. The study addresses the common issue of post-hemodialysis fatigue, which is often underestimated by healthcare providers, aiming to better understand factors influencing recovery time. Participants will receive either high sodium dialysate (141 mmol/L) or low sodium dialysate (136 mmol/L) during their hemodialysis treatments. Each treatment period lasts 8 weeks. The study is designed as a randomized trial comparing these two sodium concentration settings to observe their effects on recovery time and other health measures. During the study, participants will be assessed at baseline, week 4, and week 8 for changes in dialysis recovery time, plasma sodium levels, weight gain between dialysis sessions, blood pressure, and the occurrence of symptoms such as low blood pressure during dialysis, muscle cramps, and headaches. These evaluations help researchers monitor patient responses and safety over the 8-week treatment periods.
CONDITIONS
Brief Title
Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients with end-stage renal disease prescribed long-term hemodialysis undergoing four-hour sessions three times a week for more than 90 days
- Patients at least 18 years old
- Able to read and write
- In complete mental health
You will not qualify if you...
- Inability to complete surveys due to reading or hearing difficulties
- Clinical instability requiring hospitalization
- Dementia
- Active malignancy
- Liver failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - 8 weeks
Participants receive either high or low dialysate sodium concentration during hemodialysis sessions.
Three hemodialysis sessions per week for 8 weeks
Trial Site Locations
Total: 2 locations
1
Faculty of Medicine, Aexandria University
Alexandria, Egypt, 21526
Not Yet Recruiting
2
Faculty of Medicine, Alexandria University
Alexandria, Egypt
Actively Recruiting
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Research Team
M
Mohamed Mamdouh Elsayed, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
The prevalence of symptoms in end-stage renal disease: a systematic review.
Fliss E M Murtagh, Julia Addington-Hall, Irene J Higginson
https://pubmed.ncbi.nlm.nih.gov/17200048Prevalence, severity, and importance of physical and emotional symptoms in chronic hemodialysis patients.
Steven D Weisbord, Linda F Fried, Robert M Arnold...
https://pubmed.ncbi.nlm.nih.gov/15975996Renal provider recognition of symptoms in patients on maintenance hemodialysis.
Steven D Weisbord, Linda F Fried, Maria K Mor...
https://pubmed.ncbi.nlm.nih.gov/17702730Minutes to recovery after a hemodialysis session: a simple health-related quality of life question that is reliable, valid, and sensitive to change.
Robert M Lindsay, Paul A Heidenheim, Gihad Nesrallah...
https://pubmed.ncbi.nlm.nih.gov/17699312Recovery time, quality of life, and mortality in hemodialysis patients: the Dialysis Outcomes and Practice Patterns Study (DOPPS).
Hugh C Rayner, Lindsay Zepel, Douglas S Fuller...
https://pubmed.ncbi.nlm.nih.gov/24529994