Comparing Low and High Dialysate Sodium Levels During Hemodialysis to See Effects on Recovery Time

What this Trial Is About

This research evaluates the impact of different sodium levels in dialysate on the time it takes patients to recover after hemodialysis. It focuses on patients with chronic kidney disease undergoing long-term hemodialysis, a group known to suffer frequent fatigue that affects their quality of life. The study addresses the common issue of post-hemodialysis fatigue, which is often underestimated by healthcare providers, aiming to better understand factors influencing recovery time. Participants will receive either high sodium dialysate 141 mmolL or low sodium dialysate 136 mmolL during their hemodialysis treatments. Each treatment period lasts 8 weeks. The study is designed as a randomized trial comparing these two sodium concentration settings to observe their effects on recovery time and other health measures. During the study, participants will be assessed at baseline, week 4, and week 8 for changes in dialysis recovery time, plasma sodium levels, weight gain between dialysis sessions, blood pressure, and the occurrence of symptoms such as low blood pressure during dialysis, muscle cramps, and headaches. These evaluations help researchers monitor patient responses and safety over the 8-week treatment periods.

Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time