Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients

What this Trial Is About

Researchers are studying resistant arterial hypertension, a serious condition where high blood pressure remains elevated despite treatment. This condition increases risks for heart disease, stroke, kidney failure, and death. The study aims to evaluate if nitrate supplementation from beetroot powder can improve blood pressure and microvascular function in these patients. Beetroot powder is being considered as a simpler way to boost nitric oxide, which helps widen blood vessels. Participants are randomly assigned to one of two groups: one receives beetroot extract powder containing 400mg of nitrate daily, taken as 10 grams orally, while the other group receives a placebo supplement made of maltodextrin that matches the beetroot powder in color and flavor. The study is designed with quadruple masking to keep participants and staff unaware of group assignments. The main treatment period lasts 60 days. During the trial, participants will have their blood pressure monitored regularly to assess changes over the 60-day period. Researchers will track how blood pressure evolves and may evaluate systemic microvascular function. The total duration of participation corresponds to the treatment period, with safety and adherence monitored throughout. This study is led by the National Institute of Cardiology in Brazil and aims to provide clearer evidence on nitrate supplementation's effects in resistant hypertension.

Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients