Comparing Pre-injection Versus Standard Injection of Rocuronium for Faster Muscle Relaxation and Stable Blood Pressure During General Anesthesia Induction

What this Trial Is About

Researchers are studying adults aged 18 to 65 undergoing elective surgery under general anesthesia to compare two ways of giving the muscle relaxant drug rocuronium. The goal is to see if giving a small pre-injection dose before the main dose can speed up how quickly muscles relax while keeping blood pressure stable. This is a controlled, randomized trial involving 108 patients to evaluate the timing of neuromuscular blockade and effects on hemodynamics. Participants are randomly assigned to one of two groups. One group receives a low pre-injection dose of rocuronium followed by the main dose three minutes later. The other group receives a standard single bolus dose of rocuronium. All participants also get standard anesthesia drugs midazolam and propofol. The study compares muscle relaxation onset time and monitors blood pressure, heart rate, cardiac output, and other heart function measurements during the first 5 minutes after rocuronium injection. During the study, patients are monitored closely for muscle relaxation timing, injection pain, limb withdrawal response, and any adverse events from anesthesia until surgery ends. Vital signs are recorded at baseline and several points after the drug is given. Researchers track safety and heart function throughout the perioperative period. The total participation includes the induction of anesthesia through surgery with detailed assessments in the initial minutes after rocuronium administration.

Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction