Actively Recruiting
Led by Pennington Biomedical Research Center · Updated on 2025-01-16
12
Participants Needed
1
Research Sites
N/A
Total Duration
This research evaluates insulin sensitivity in people with obesity and insulin resistance by comparing two methods of insulin infusion during the hyperinsulinemic euglycemic clamp test. The study aims to understand how delivering insulin in pulses versus continuously affects insulin action, which helps control blood sugar levels. The trial is a controlled, non-randomized, two-arm study involving participants who have completed a previous related study called Motivate. Participants will undergo two clamp tests within a week. In the first test, insulin is infused continuously at a set dose. In the second, the same total insulin dose is given in pulses every five minutes. Following these tests, participants will return after fasting for blood samples to measure glucose and insulin levels. Throughout the study, researchers will monitor insulin sensitivity primarily, with insulin resistance as a secondary measure. The total participation involves returning for two clamp tests and a fasting blood draw, all occurring within a short timeframe. The study does not use masking or placebos and is led by the Pennington Biomedical Research Center.
CONDITIONS
Effect of Pulsatile Hormone Administration on Insulin Action
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Within 1 week
Participants complete two hyperinsulinemic euglycemic clamp tests to receive insulin either continuously or in pulses every five minutes.
2 visits for clamp tests within a week
Duration - 1 day
Participants return the day after the clamp tests in a fasted state for blood draws to measure glucose and insulin.
1 visit (in-person)
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
C
Candida J Rebello, Ph.D.
F
Frank L Greenway, MD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Candida J Rebello, Tyler S Morales, Katsya Chuon...
https://pubmed.ncbi.nlm.nih.gov/37580916