Actively Recruiting
Effect of Pulsatile Hormone Administration on Insulin Action
Led by Pennington Biomedical Research Center · Updated on 2025-01-16
12
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.
CONDITIONS
Official Title
Effect of Pulsatile Hormone Administration on Insulin Action
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completion of the Motivate Study (NCT05649176)
You will not qualify if you...
- Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
Research Team
C
Candida J Rebello, Ph.D.
CONTACT
F
Frank L Greenway, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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